NCT05177523 Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
| NCT ID | NCT05177523 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Basel, Switzerland |
| Condition | Multiple Sclerosis (MS) |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2018-09-04 |
| Primary Completion | 2028-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2018-09-04 with a primary completion date of 2028-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.
Eligibility Criteria
Inclusion Criteria for patients: * Patients may be diagnosed with: 1. active RRMS (n=100): Relapsing-remitting course and \> 1 clinical relapse and/or signs of MRI activity (\> 1 Gd enhancing lesion) during the last year before study enrollment. 2. non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment. * Age 18-80 years old * No other neurological or psychiatric disorder Inclusion criteria for healthy controls: * Age 18-80 years old * No other neurological or psychiatric disorder Exclusion Criteria for patients and healthy controls: * Pregnancy * Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc). * Inability to give consent
Contact & Investigator
Cristina Granziera, Prof. Dr. med.
PRINCIPAL INVESTIGATOR
Department of Neurology, University Hospital Basel
Frequently Asked Questions
Who can join the NCT05177523 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Multiple Sclerosis (MS). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05177523 currently recruiting?
Yes, NCT05177523 is actively recruiting participants. Contact the research team at cristina.granziera@usb.ch for enrollment information.
Where is the NCT05177523 trial being conducted?
This trial is being conducted at Basel, Switzerland.
Who is sponsoring the NCT05177523 clinical trial?
NCT05177523 is sponsored by University Hospital, Basel, Switzerland. The principal investigator is Cristina Granziera, Prof. Dr. med. at Department of Neurology, University Hospital Basel. The trial plans to enroll 300 participants.
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