NCT07301307 Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
| NCT ID | NCT07301307 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National and Kapodistrian University of Athens |
| Condition | Intraoperative Hypotension |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-03-15 |
| Primary Completion | 2026-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2026-03-15 with a primary completion date of 2026-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia. The main question is : Does the HPI and AFM software reduce the incidence and duration of intraoperative hypotension? Does the HPI and AFM software optimize fluid and vasopressor administration? Does the HPI and AFM software improve perioperative outcomes? Participants will be randomly allocated to either an experimental group receiving goal directed hemodynamic therapy guided by HPI and AFM or a control group receiving conventional hemodynamic management.
Eligibility Criteria
Inclusion Criteria: * Age \> 18 years * Intraoperative monitoring \> 2 hours or general anesthesia \> 2 hours * Invasive arterial pressure monitoring * Target MAP ≥ 65 mm Hg intraoperatively * Written informed consent preoperatively * ASA Physical Status ≤ 4 Exclusion Criteria: * Target MAP other than 65 mm Hg * Severe preoperative hypotension (MAP \< 65 mm Hg) * Severe heart failure (e.g. LVEF \< 20%) * Emergency surgery
Contact & Investigator
Georgia Ntalamagka, MD
PRINCIPAL INVESTIGATOR
Attikon Hospital
Frequently Asked Questions
Who can join the NCT07301307 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Intraoperative Hypotension. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07301307 currently recruiting?
Yes, NCT07301307 is actively recruiting participants. Contact the research team at geo.dalamaga@gmail.com for enrollment information.
Where is the NCT07301307 trial being conducted?
This trial is being conducted at Athens, Greece.
Who is sponsoring the NCT07301307 clinical trial?
NCT07301307 is sponsored by National and Kapodistrian University of Athens. The principal investigator is Georgia Ntalamagka, MD at Attikon Hospital. The trial plans to enroll 100 participants.