NCT07814235 Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging
| NCT ID | NCT07814235 |
| Status | Recruiting |
| Phase | — |
| Sponsor | IVI Murcia |
| Condition | Aging |
| Study Type | OBSERVATIONAL |
| Enrollment | 45 participants |
| Start Date | 2026-06-10 |
| Primary Completion | 2027-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 45 participants in total. It began in 2026-06-10 with a primary completion date of 2027-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age. Men aged 18 years and older will provide a semen sample and a blood sample for laboratory analysis. Each semen sample will be divided into fresh, slow-frozen, and vitrified aliquots. The study will compare sperm quality (as assessed by computer-assisted sperm analysis), DNA methylation profiles, DNA fragmentation, sperm telomere length before and after cryopreservation. The effects of age on these parameters will also be assessed. The impact of age on seminal plasma extracellular vesicle composition and blood cell telomere length will also be analysed. The goal is to determine whether sperm cryopreservation may represent a strategy for preserving sperm characteristics associated with younger paternal age.
Eligibility Criteria
Inclusion Criteria: * Male participants aged 18 to 65 years * Attending IVI Murcia for semen analysis and/or assisted reproduction treatment * Able and willing to provide written informed consent * Willing to provide a semen sample and a blood sample for research purposes Exclusion Criteria: * Previous diagnosis of azoospermia or severe oligozoospermia (sperm concentration \<1 million sperm/mL) * Known chromosomal abnormality (abnormal karyotype) * Known Y chromosome microdeletion * Febrile illness within the previous 3 months * Presence of varicocele * Current use of vitamin or antioxidant supplements intended to improve semen quality
Frequently Asked Questions
Who can join the NCT07814235 clinical trial?
This trial is open to male participants only, aged 18 Years or older, up to 65 Years, studying Aging. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07814235 currently recruiting?
Yes, NCT07814235 is actively recruiting participants. Visit ClinicalTrials.gov or contact IVI Murcia to inquire about joining.
Where is the NCT07814235 trial being conducted?
This trial is being conducted at Murcia, Spain.
Who is sponsoring the NCT07814235 clinical trial?
NCT07814235 is sponsored by IVI Murcia. The trial plans to enroll 45 participants.