NCT07199907 Hippocampal and Frontoparietal Development and Inference
| NCT ID | NCT07199907 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Texas at Austin |
| Condition | Healthy |
| Study Type | INTERVENTIONAL |
| Enrollment | 142 participants |
| Start Date | 2025-02-20 |
| Primary Completion | 2029-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 142 participants in total. It began in 2025-02-20 with a primary completion date of 2029-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to test if an intervention used to manipulate memory and inference can improve our understanding of how brain development supports these abilities in healthy adolescent and adult volunteers. The main questions it aims to answer are: (1) Do hippocampus and ventromedial prefrontal cortex shift from forming simple memories for singular experiences to more complex memories that link numerous experiences together?; (2) Does an improved ability to retrieve prior memories in parietal cortex during new learning have consequences for how those memories are organized at different ages?; and (3) Does the emerging memory control supported by ventromedial prefrontal cortex development facilitate the formation of optimally-organized memory representations? Adolescent participants (13-18 years) will perform two experimental tasks during functional magnetic resonance imaging (fMRI) scanning at three timepoints (T1-T3), spaced 1.5 years apart. Researchers will compare behavioral and neuroimaging data to a separate group of adults (19-25 years) who will perform the task at a single timepoint (T1). The tasks and comparison groups will allow us to isolate the neural processes that support memory and inference behavior, and how these processes change with age.
Eligibility Criteria
Inclusion Criteria: * Right-handed * Have normal or corrected to normal vision * Have normal hearing * Do not have contraindications for MRI * Have no history of neurological or psychiatric disorders at initial intake * Are of normal intelligence * Native or fluent English speaker Exclusion Criteria: * A major medical illness or a neurological disorder, or neurological abnormality including significant head trauma (loss of consciousness \> 5 min). * Meeting criteria for any psychiatric disorder or any prior psychiatric hospitalizations * Intelligence scores more than 1 standard deviation below the mean on the WASI-II * History of special education placement * Non-native English speaker * Prior use of psychotropic medication, except antidepressants, for longer than 1 month * History of moderate to severe cannabis use disorder, via self-report * MRI exclusions: Claustrophobia; tattoos above the shoulders; permanent eyeliner; permanent retainer or spacer; artificial eyebrows; cardiac pacemaker; metal fragments in eye, skin, or body, including shrapnel; heart valve replacement; brain clips; venous umbrella; being a sheet-metal worker or welder; lifetime history of aneurysm surgery; intracranial bypass, renal, or aortic clips; prosthetic devices such as middle ear, eye, joint, or penile implants; joint replacements; non-removable hearing aid, neurostimulator, or insulin pump; shunts/stents; metal mesh/coil implants; metal plate/pin/screws/wires; or any other metal implants; or suspected pregnancy.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07199907 clinical trial?
This trial is open to participants of all sexes, aged 13 Years or older, up to 25 Years, studying Healthy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07199907 currently recruiting?
Yes, NCT07199907 is actively recruiting participants. Contact the research team at apreston@utexas.edu for enrollment information.
Where is the NCT07199907 trial being conducted?
This trial is being conducted at Austin, United States.
Who is sponsoring the NCT07199907 clinical trial?
NCT07199907 is sponsored by University of Texas at Austin. The trial plans to enroll 142 participants.