NCT07227545 High Intensity Alternating Current Stimulation as a Neuromodulation Therapy for Alcohol Use Disorder: A Pilot Study
| NCT ID | NCT07227545 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shanghai Mental Health Center |
| Condition | Alcohol Use Disorder (AUD) |
| Study Type | INTERVENTIONAL |
| Enrollment | 18 participants |
| Start Date | 2026-10-11 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 18 participants in total. It began in 2026-10-11 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This one-arm pilot study aims to evaluate the preliminary clinical, behavioral, and neurophysiological effects of high-intensity transcranial alternating current stimulation (HI-tACS) in individuals with alcohol use disorder (AUD). Participants will receive HI-tACS and undergo clinical and neurophysiological assessments before and after the intervention.
Eligibility Criteria
Inclusion Criteria: * Education level of junior high school or above, capable of completing questionnaires and behavioral tests; * Aged 18-60 years; * Meet DSM-5 diagnostic criteria for Alcohol Use Disorder; * No abnormal findings on physical examination; * Agree to participate in follow-up assessments; * No contraindications for MRI scanning. Exclusion criteria: * Have impaired intelligence (Intelligence Quotient\<70); * Prior tDCS or TMS treatment within the past 3 months; * Contraindications for TMS therapy (e.g., intracranial metal implants, history of traumatic brain injury, skull defects, cardiac pacemakers, cardiovascular diseases, or epilepsy); * Severe somatic diseases or major organ dysfunction; * Psychiatric disorders per DSM-5 criteria (e.g., schizophrenia, schizoaffective disorder, intellectual disability, autism spectrum disorder, dementia, memory impairment, or other cognitive disorders). * Psychiatric disorders per DSM-5 criteria (e.g., schizophrenia, schizoaffective disorder, intellectual disability, autism spectrum disorder, dementia, memory impairment, or other cognitive disorders). * Diagnosis of other substance-related and addictive disorders or behavioral addictions.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07227545 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Alcohol Use Disorder (AUD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07227545 currently recruiting?
Yes, NCT07227545 is actively recruiting participants. Contact the research team at dujiangdou@163.com for enrollment information.
Where is the NCT07227545 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT07227545 clinical trial?
NCT07227545 is sponsored by Shanghai Mental Health Center. The trial plans to enroll 18 participants.