NCT04060706 Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy
| NCT ID | NCT04060706 |
| Status | Recruiting |
| Phase | — |
| Sponsor | CCTU- Cancer Theme |
| Condition | Cancer |
| Study Type | OBSERVATIONAL |
| Enrollment | 310 participants |
| Start Date | 2019-09-11 |
| Primary Completion | 2023-01-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 310 participants in total. It began in 2019-09-11 with a primary completion date of 2023-01-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The Hamlet.rt study is a prospective data collection and patient questionnaire study for patients undergoing image-guided radiotherapy with curative intent. The aim of the study is to use novel machine learning and mathematical techniques to build a model that can predict the risk of significant side effects from radiotherapy treatment for an individual patient: using calculations of normal tissue dose from radiotherapy treatment planning and patient baseline characteristics derived from image and non-image data, continuously updated as the patient is reviewed both during and after treatment. A secondary goal of the project is to facilitate research in machine learning and medical image processing for radiation therapy through the creation of a discoverable and shared data resource for research use.
Eligibility Criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Male or Female * Aged 18 years or older * Diagnosed with primary prostate cancer, head and neck cancer, lung cancer, or brain tumour * Treated with curative intent * Suitable for radical image guided radiotherapy * WHO ECOG performance status 0 or 1 * Expected survival of 18 months or more Exclusion Criteria: * Participant is not willing or able to complete the protocol-stated requirements of the study, e.g. accessing \& completing web-based long-term follow-up questionnaires.
Contact & Investigator
Raj Dr. Jena
PRINCIPAL INVESTIGATOR
Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge
Frequently Asked Questions
Who can join the NCT04060706 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04060706 currently recruiting?
Yes, NCT04060706 is actively recruiting participants. Contact the research team at meena.murthy@addenbrookes.nhs.uk for enrollment information.
Where is the NCT04060706 trial being conducted?
This trial is being conducted at Cambridge, United Kingdom.
Who is sponsoring the NCT04060706 clinical trial?
NCT04060706 is sponsored by CCTU- Cancer Theme. The principal investigator is Raj Dr. Jena at Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge. The trial plans to enroll 310 participants.
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