NCT04046796 Genetic Causes of Discrepant Clinic in Monogenic Twins
| NCT ID | NCT04046796 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital Tuebingen |
| Condition | Rare Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 50 participants |
| Start Date | 2019-12-01 |
| Primary Completion | 2025-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 50 participants in total. It began in 2019-12-01 with a primary completion date of 2025-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.
Eligibility Criteria
Inclusion Criteria: * Twin pair monozygotic clinically (phenotypic) discordant twins * Unclear diagnosis * Suspected (mono-)genetic cause of the disease in one twin Exclusion Criteria: * Missing informed consent of both twin/ legal representative * No distinct phenotype
Contact & Investigator
Jeannette Hübener-Schmid, Dr.
PRINCIPAL INVESTIGATOR
University Hospital Tübingen
Frequently Asked Questions
Who can join the NCT04046796 clinical trial?
This trial is open to participants of all sexes, studying Rare Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04046796 currently recruiting?
Yes, NCT04046796 is actively recruiting participants. Contact the research team at jeannette.huebener@med.uni-tuebingen.de for enrollment information.
Where is the NCT04046796 trial being conducted?
This trial is being conducted at Tübingen, Germany.
Who is sponsoring the NCT04046796 clinical trial?
NCT04046796 is sponsored by University Hospital Tuebingen. The principal investigator is Jeannette Hübener-Schmid, Dr. at University Hospital Tübingen. The trial plans to enroll 50 participants.
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