NCT07258186 Generation of Endometrial Carcinoma Organoids
| NCT ID | NCT07258186 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Regina Elena Cancer Institute |
| Condition | Endometrial Cancer |
| Study Type | OBSERVATIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-03-23 |
| Primary Completion | 2028-09-23 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 20 participants in total. It began in 2025-03-23 with a primary completion date of 2028-09-23.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice. Samples will be collected from collaborating extramural facilities, with the aim of analyzing the impact of transport on tissue viability and the success of organoid culture. This study is for exploratory purposes only, without altering the diagnostic and therapeutic pathways of the participants.
Eligibility Criteria
Inclusion Criteria: * Age \>18 years; * Patients with a histological diagnosis of: endometrial cancer, endometrioid histology, any stage of disease (FIGO I-IV), recurrence/metastasis from endometrial endometrioid cancer, and candidates for surgery and/or hysterectomy; * Written informed consent (study participation and data processing) must be obtained in person and/or through a legal representative/guardian/support administrator/witness, before any study-specific procedure is performed. Exclusion Criteria: * Comorbidities not controlled with adequate medical therapy; * Endometrial cavity infections (pyometra); * Synchronous tumors; * Neoadjuvant treatments; * Previous radiation treatments to the pelvic region.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07258186 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Endometrial Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07258186 currently recruiting?
Yes, NCT07258186 is actively recruiting participants. Contact the research team at giovanni.blandino@ifo.it for enrollment information.
Where is the NCT07258186 trial being conducted?
This trial is being conducted at Roma, Italy.
Who is sponsoring the NCT07258186 clinical trial?
NCT07258186 is sponsored by Regina Elena Cancer Institute. The trial plans to enroll 20 participants.
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