NCT07474363 Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive Disorder
| NCT ID | NCT07474363 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Eskisehir Osmangazi University |
| Condition | Major Depressive Disorder (MDD) |
| Study Type | OBSERVATIONAL |
| Enrollment | 90 participants |
| Start Date | 2025-06-01 |
| Primary Completion | 2026-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 90 participants in total. It began in 2025-06-01 with a primary completion date of 2026-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Depression is a common and serious mental health condition that affects mood, thoughts, behavior, and overall quality of life. It arises from a complex interaction of biological, psychological, and environmental factors. While depression is more frequently diagnosed in women, research suggests that men may experience and express depressive symptoms differently. Men are more likely to display symptoms such as irritability, anger, impulsivity, or increased alcohol use, and they may be less likely to seek professional psychological support due to social expectations and fear of stigma. Stigma-both self-stigma (internalized negative beliefs about having a mental illness) and perceived social stigma (concerns about being judged by others)-can negatively influence individuals' willingness to seek help and adhere to treatment. In addition, psychological resilience, defined as the ability to cope effectively with stress and adversity, may play an important role in how individuals experience depressive symptoms and respond to treatment. This study aims to compare women and men diagnosed with Major Depressive Disorder in terms of depression severity, gender-sensitive depressive symptoms, self-stigma, perceived social stigma, and levels of psychological resilience. It will also examine the relationships among these factors to better understand how gender-related differences influence the experience and management of depression. Findings from this study may contribute to improved recognition of gender-specific features of depression, reduction of stigma, and the development of more individualized and effective mental health interventions for both women and men.
Eligibility Criteria
Inclusion Criteria: * Male and female patients aged 18 to 65 years * Diagnosis of Major Depressive Disorder according to DSM-5 at the time of study participation * Provision of voluntary informed consent Exclusion Criteria: * Intellectual disability * Severe neurological disorders * Comorbid psychiatric diagnoses * Depressive disorder secondary to an organic medical condition * Depressive disorder secondary to substance use
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07474363 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Major Depressive Disorder (MDD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07474363 currently recruiting?
Yes, NCT07474363 is actively recruiting participants. Contact the research team at irem.ozkaynak@ogu.edu.tr for enrollment information.
Where is the NCT07474363 trial being conducted?
This trial is being conducted at Eskişehir, Turkey (Türkiye).
Who is sponsoring the NCT07474363 clinical trial?
NCT07474363 is sponsored by Eskisehir Osmangazi University. The trial plans to enroll 90 participants.