NCT07829237 FueL Use During eXercise in Males and Females
| NCT ID | NCT07829237 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Toronto |
| Condition | Healthy Adults |
| Study Type | INTERVENTIONAL |
| Enrollment | 24 participants |
| Start Date | 2026-09-30 |
| Primary Completion | 2027-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 24 participants in total. It began in 2026-09-30 with a primary completion date of 2027-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will investigate whether pre-exercise nutrition influences sex differences in fuel utilization during endurance exercise. Twenty-four recreationally active adults (12 females and 12 males) will complete three experimental exercise trials in a randomized, counterbalanced crossover design. Before each trial, participants will consume either a carbohydrate beverage, a protein-based beverage, or a flavour-matched non-caloric beverage representing the fasted condition. Thirty minutes later, participants will complete 90 minutes of moderate-intensity cycling followed by a cycling time-to-task-failure test. Whole-body carbohydrate and fat oxidation, exogenous substrate oxidation, blood metabolites, and exercise performance will be assessed.
Eligibility Criteria
Inclusion Criteria: * Participating in ≥150 minutes of moderate-to-vigorous physical activity per week * VO₂peak classified as "good" or above based on American College of Sports Medicine normative values: \>35.0 mL/kg/min for females and \>39.0 mL/kg/min for males * Body mass index (BMI) between 18 and 27 kg/m² * Participating in 3-5 structured exercise sessions per week * Weight stable, defined as within ±2 kg for at least 6 months * Non-smoker * Females must be eumenorrheic Exclusion Criteria: * Polycystic ovarian syndrome (PCOS) or endometriosis Current use of oral contraceptives or oral contraceptive use within the previous 3 months Diagnosed cardiovascular or metabolic disease Hypergonadism or hypogonadism Use of medications for management of blood glucose or lipid metabolism Pregnant or \<12 months postpartum Lactating or breastfeeding within 3 months of study commencement Menopausal Recreational tobacco smoking Inability to complete the study exercise protocols or comply with pre-trial dietary or physical activity controls Use of medications that may affect substrate metabolism, including corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) Currently following a low-carbohydrate diet, such as a ketogenic or Atkins diet
Contact & Investigator
Jenna Gillen, PhD
PRINCIPAL INVESTIGATOR
University of Toronto
Frequently Asked Questions
Who can join the NCT07829237 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 35 Years, studying Healthy Adults. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07829237 currently recruiting?
Yes, NCT07829237 is actively recruiting participants. Contact the research team at jenna.gillen@utoronto.ca for enrollment information.
Where is the NCT07829237 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT07829237 clinical trial?
NCT07829237 is sponsored by University of Toronto. The principal investigator is Jenna Gillen, PhD at University of Toronto. The trial plans to enroll 24 participants.