NCT06700187 Frequency of Interrupting Sitting and Cognitive Function
| NCT ID | NCT06700187 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Maastricht University Medical Center |
| Condition | Sedentary Behaviors |
| Study Type | INTERVENTIONAL |
| Enrollment | 33 participants |
| Start Date | 2024-10-03 |
| Primary Completion | 2026-03-27 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 33 participants in total. It began in 2024-10-03 with a primary completion date of 2026-03-27.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Rationale: Sedentary behavior (SB) has been associated with impaired cognitive function in elderly, and negatively impacts glucose metabolism. Interrupting sitting with physical activity (PA) bouts may exert beneficial effects on cognitive function via an improved glucose metabolism. Nevertheless, the impact of breaking up prolonged sitting with various frequencies of PA bouts remains unexplored in young sedentary adults. Moreover, we hypothesize that the pattern of the breaks modifies the effects. Thus, randomized controlled trials (RCTs) are highly needed to investigate the effects of interrupting sitting with different frequencies of PA on cognitive function and glucose metabolism. We now hypothesize that interrupting sitting with different frequencies of walking breaks differentially affects cognitive function and glucose metabolism. Objective: The aim is to investigate the effects of breaking up sitting with different frequencies of PA bouts on cognitive function and glucose metabolism in young sedentary adults. Study design: A randomised, controlled cross-over study will be performed, consisting of four interventions in a counterbalanced order: uninterrupted prolonged sitting, short breaks, moderate breaks, and long breaks. Intervention: Participants will complete four conditions in a randomized, counterbalanced order: sitting (uninterrupted prolonged sitting without any interruptions), short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes during the intervention). Each condition lasts 4.5 hours.
Eligibility Criteria
Inclusion Criteria: * Men and women aged 18-35 years; * BMI between 18.5-24.9 kg/m2; * SB, i.e. sitting for an average of at least 9 hours per day; * Physically inactive, i.e. engaging in exercise for less than 2 to 3 times per week; * Stable body weight (weight gain or loss \< 3 kg in the past three months); * Willingness to engage in four 6-hour laboratory visits; * No difficult cannulation. Exclusion Criteria: * Not sedentary, i.e. sitting for less than an average of 9 hours per day; * Physically active, i.e. engaging in exercise for more than 3 times a week; * Abuse of drugs; * Use medication to treat BP, lipid, or glucose metabolism; * Pregnant females.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06700187 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 35 Years, studying Sedentary Behaviors. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06700187 currently recruiting?
Yes, NCT06700187 is actively recruiting participants. Contact the research team at renyan.ma@maastrichtuniversity.nl for enrollment information.
Where is the NCT06700187 trial being conducted?
This trial is being conducted at Maastricht, Netherlands.
Who is sponsoring the NCT06700187 clinical trial?
NCT06700187 is sponsored by Maastricht University Medical Center. The trial plans to enroll 33 participants.