NCT05790356 Fecal Microbial Transplantation for Rheumatoid Arthritis Trial
| NCT ID | NCT05790356 |
| Status | Recruiting |
| Phase | — |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Condition | Arthritis |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2023-08-01 |
| Primary Completion | 2025-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2023-08-01 with a primary completion date of 2025-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This clinical trial will investigate the effects of capsules containing stool from healthy donors, called fecal microbial transplant (FMT), in rheumatoid arthritis patients.
Eligibility Criteria
Inclusion Criteria: * 18-years old or older * RA diagnosis by ACR/EULAR criteria \[26\] * Positive for the RA-associated antibodies, anti-citrullinated protein/peptide antibodies (ACPA) and/or rheumatoid factor (RF) * Stable RA therapy \> 6 months * Patient in remission or low disease activity by DAS28 * Consents to study Fecal Donor Inclusion Criteria: * A healthy donor who has a normal body mass index (BMI of 18.5-30) and who satisfies the following criteria will be selected from a pool of donors available in the Infectious Diseases clinic at St. Joseph's Hospital supervised by Dr. Silverman and screened for all transmissible agents. at the Microbiology and Immunology lab at St. Joseph's Hospital under Dr. Silverman for the study and screened for transmissible agents. Exclusion Criteria: * Pregnant or breastfeeding * Current or recent \[in the last 60 days\] exposure to high dose oral (\>30 mg of prednisone daily or equivalent), IV corticosteroids, biologic therapies or JAKi. * Patients who require inhaled steroids or local steroid injections are not excluded from the study * Has a diagnosis of immunodeficiency (HIV, transplantation, or autoimmune disease other than RA requiring immunosuppressive therapies), or currently receiving systemic steroid therapy (\>10 mg prednisone daily or equivalent) * Received rituximab or other chemotherapeutic agent in the last 2 years. * Expected to require any other form of systemic or localized anti-neoplastic therapy while on study * Has a known history of a hematologic malignancy, primary brain tumor or sarcoma, or of another primary solid tumor, unless the patient has undergone potentially curative therapy with no evidence of that disease for five years. NOTE: This time requirement also does not apply to patients who underwent successful definitive resection of basal or squamous cell carcinoma of the skin, superficial bladder cancer, in situ cancers including cervical cancer, breast cancer, melanoma, or other in situ cancers. * Ongoing use of antibiotics/anti-virals or previous use of antibiotics/anti-virals in the last 3 months prior to the FMT procedure * Has an active infection requiring systemic therapy or requiring hospital admission in last 3 months. * Presence of a chronic intestinal disease (e.g. Celiac disease, malabsorption, colonic tumor, IBD) * Presence of absolute contra-indications to FMT administration * Toxic megacolon * Anaphylactic allergic reactions to food (e.g. shellfish, nuts, seafood, eggs) * Has serious uncontrolled concomitant illnesses, such as: cardiovascular disease (uncontrolled congestive heart failure, hypertension, cardiac ischemia, myocardial infarction, and severe cardiac arrhythmia), severe obstructive or restrictive pulmonary diseases, cirrhosis or ALT\>100, renal disease with GFR\<50 and uncontrolled psychiatric illness. * Patient has received a live vaccine within 4 weeks prior to the first dose of treatment * Insulin-dependent diabetes * Previous bariatric surgery * Chronic neutropenia (\<0.5) Currently participating in another clinical trial Fecal Donor Exclusion Criteria: * Any underlying metabolic disease including; hypertension, hyperlipidemia, diabetes, insulin insensitivity, atherosclerosis * A history of any gastrointestinal or liver disorders or cancers. Including but not limited to; gastroesophageal reflux, peptic ulcer disease, celiac disease, inflammatory bowel disease (Crohn's disease or ulcerative colitis), microscopic colitis, motility disorders (including gastroparesis and irritable bowel syndrome) diverticular disease * Previous surgery to the intestine, liver or gallbladder (except remote appendectomy) * History of any malignancy * Use within 3 months of any antibiotics * Hospitalization within 3 months * Recent travel to a developing country (within 3 months). * New Sexual Partner (within 3 months) * Street drug use, family history of diabetes, early onset coronary disease or gastrointestinal or liver disease, colon cancer, familial malignancy * Psychiatric history (major affective disorder, psychotic illness, ongoing use of any psychiatric medications) * Any positive laboratory results for a transmissible pathogen * Alcohol intake with a cut off value of \<10g/d in women and \<20g/d in men * Currently participating in another clinical trial that may alter fecal composition.
Contact & Investigator
Lillian Barra, MD, MPH
PRINCIPAL INVESTIGATOR
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Frequently Asked Questions
Who can join the NCT05790356 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Arthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05790356 currently recruiting?
Yes, NCT05790356 is actively recruiting participants. Contact the research team at Lillian.Barra@sjhc.london.on.ca for enrollment information.
Where is the NCT05790356 trial being conducted?
This trial is being conducted at London, Canada.
Who is sponsoring the NCT05790356 clinical trial?
NCT05790356 is sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. The principal investigator is Lillian Barra, MD, MPH at London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. The trial plans to enroll 30 participants.