NCT06366529 Explore New Magnetic Resonance Technology in Assessment of Renal Dysfunction
| NCT ID | NCT06366529 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhen Li |
| Condition | Renal Insufficiency, Chronic |
| Study Type | OBSERVATIONAL |
| Enrollment | 500 participants |
| Start Date | 2023-09-01 |
| Primary Completion | 2030-09 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 500 participants in total. It began in 2023-09-01 with a primary completion date of 2030-09.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Currently, renal biopsy is the gold standard for evaluating renal pathology and renal fibrosis, but it is invasive and carries the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is prone to sampling bias. The lack of reliable, comprehensive test results has hindered the research of new anti-fibrotic drugs and delayed the clinical application of effective new drugs. Therefore, the development of a non-invasive dynamic detection method for renal insufficiency and renal fibrosis in vivo is an urgent clinical problem to be solved. With the continuous development and update of technology, imaging provides a new way to non-invasively evaluate renal fibrosis. Due to the high resolution of soft tissue and the ability to perform multi-parameter analysis, magnetic resonance has developed the diagnosis of renal insufficiency and renal fibrosis from macroscopic simple biomorphological changes to microscopically complex pathophysiological changes. Many imaging techniques measure renal dysfunction and renal fibrosis by assessing the impact of fibrosis on the functional status, physical properties, and molecular properties of the kidney. In recent years, in the context of precision medicine, artificial intelligence technologies such as radiomics and machine learning are rapidly becoming very promising auxiliary tools in the imaging assessment of renal fibrosis. It can extract and learn features in images with high throughput, make greater use of information in medical images that cannot be recognized by the human eye, and achieve disease diagnosis, prognosis assessment, and efficacy prediction by building models. However, most of the current research is in the preliminary stage, and there are still few studies on the assessment of renal insufficiency and renal fibrosis. I believe that with the continuous improvement of algorithms and the optimization of models, the progress of radiomics and machine learning will be great. To a certain extent, it promotes the development of personalized medicine and precision medicine for patients with renal insufficiency and renal fibrosis.
Eligibility Criteria
Inclusion Criteria: 1. Patients with clinically suspected or confirmed renal insufficiency and prescribed MR examination; 2. Age/gender: no limit; 3. Patients who voluntarily participate in clinical trials and sign written informed consent forms Exclusion Criteria: 1. Patients with pacemakers of unknown material, metal implants in the body, neurostimulators, and claustrophobia, etc. 2. Patients who cannot tolerate sufficient breath-holding for adequate MR examination
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06366529 clinical trial?
This trial is open to participants of all sexes, studying Renal Insufficiency, Chronic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06366529 currently recruiting?
Yes, NCT06366529 is actively recruiting participants. Contact the research team at zhenli@hust.edu.cn for enrollment information.
Where is the NCT06366529 trial being conducted?
This trial is being conducted at Wuhan, China.
Who is sponsoring the NCT06366529 clinical trial?
NCT06366529 is sponsored by Zhen Li. The trial plans to enroll 500 participants.