NCT07561840 Exercise Training After Upper Gastrointestinal Cancer Surgery
| NCT ID | NCT07561840 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Kansai Medical University |
| Condition | Esophageal Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 171 participants |
| Start Date | 2026-05-15 |
| Primary Completion | 2029-11 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 171 participants in total. It began in 2026-05-15 with a primary completion date of 2029-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled trial aims to determine the optimal exercise intensity for improving postoperative recovery in patients with upper gastrointestinal cancer. Participants who have undergone curative surgery will be randomly assigned to high-intensity interval training (HIIT), low-intensity continuous training (LICT), or usual care. The exercise interventions will be performed under supervision three times per week for eight weeks. The primary outcome is peak oxygen uptake (VO₂peak), assessed using cardiopulmonary exercise testing. Secondary outcomes include physical function, body composition, patient-reported outcomes, and biological and mechanistic markers such as inflammatory biomarkers, muscle-related factors, and gut microbiota. This study will also explore potential mechanisms underlying exercise-induced adaptations and their association with clinical outcomes.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * Diagnosed with esophageal or gastric cancer * Received curative surgery * 6 ± 2 weeks after surgery * Ability to provide written informed consent Exclusion Criteria: * Communication difficulties * Poor general status * Undergone combined laryngopharyngectomy * Unsuitable for evaluation or exercise intervention * Unsuitable for the study as determined by the primary physician
Contact & Investigator
Takuya Fukushima
PRINCIPAL INVESTIGATOR
Kansai Medical University
Frequently Asked Questions
Who can join the NCT07561840 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Esophageal Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07561840 currently recruiting?
Yes, NCT07561840 is actively recruiting participants. Contact the research team at fukushima.tky@kmu.ac.jp for enrollment information.
Where is the NCT07561840 trial being conducted?
This trial is being conducted at Hirakata, Japan, Hirakata, Japan.
Who is sponsoring the NCT07561840 clinical trial?
NCT07561840 is sponsored by Kansai Medical University. The principal investigator is Takuya Fukushima at Kansai Medical University. The trial plans to enroll 171 participants.
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