NCT07242833 Evaluation of the Effect of Seasonality on Biological Age in Adults
| NCT ID | NCT07242833 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Société des Produits Nestlé (SPN) |
| Condition | Aging |
| Study Type | OBSERVATIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-11-24 |
| Primary Completion | 2027-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 60 participants in total. It began in 2025-11-24 with a primary completion date of 2027-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This research aims to provide insights on how seasonal variations influence biological age and enhance the design and analysis of long-term lifestyle interventions targeting biological clocks. Aging is a gradual decline in cellular and organ functions, significantly increasing the risk of non-communicable and infectious diseases. Recent research has focused on identifying aging biomarkers that can better predict functional capability in healthy individuals. Biological age clocks, which can be measured from samples like blood or saliva, are emerging as valuable tools for assessing the pace of aging and calculating age acceleration-the difference between chronological and biological age. These clocks utilize molecular and clinical data, including DNA methylation and plasma proteomics, to predict future health outcomes, such as disease risk and mortality. Various DNA methylation-based clocks have been developed, with the Dunedin Pace of Aging (PoAm) offering a more precise modeling of physiological changes over time. Lifestyle factors, including diet and physical activity, can influence age acceleration, suggesting that lifestyle interventions may impact biological aging. Current evidence indicates that three specific epigenetic clocks-PhenoAge, GrimAge, and Dunedin PACE-are particularly effective in detecting beneficial effects on aging trajectories. However, the stability of these clocks during long-term lifestyle interventions remains unclear, as they can exhibit variability over short periods and may be affected by factors influenced by seasonal changes, such as Vitamin D levels, climate, and white blood cells composition. To investigate these seasonal effects on biological age, a proposed observational study will track changes over a 12-month period in middle-aged and older adults.
Eligibility Criteria
Inclusion Criteria: 1. Males and females aged over 40 years, inclusive, at enrolment. 2. Assessed by the investigator to be in general good health or have stable, well-controlled chronic medical conditions (e.g. hypertension, type 2 diabetes, etc.) that are not expected to interfere with study participation or outcomes. (Note: stable medical condition is defined as controlled medical condition, with no change in medication, worsening of the condition, or hospitalization in the past 3 months prior to enrolment). 3. Body mass index (BMI) ≥18.5 kg/m². 4. Able to understand and to sign a written informed consent prior to study enrolment. 5. Willing and able to comply with the requirements for participation in this study. Exclusion Criteria: 1. Any past or on-going significant medical/surgical condition and/or psychiatric condition, which in the opinion of the investigator may risk participant's wellbeing/safety, impede participant compliance with study procedures or ability to complete the study and/or could confound the primary objectives of the study (such as seasonal allergy). 2. Any acute illness or any recent medical/surgical intervention, including vaccination, within 21 days prior to enrolment. 3. Female participants who are pregnant or intending to become pregnant, lactating and/or breastfeeding 4. Currently participating in another interventional research study. 5. Family or direct hierarchical relationship with the research team members.
Contact & Investigator
Carolina Stambolsky, MD
PRINCIPAL INVESTIGATOR
Nestlé Research
Frequently Asked Questions
Who can join the NCT07242833 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, studying Aging. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07242833 currently recruiting?
Yes, NCT07242833 is actively recruiting participants. Contact the research team at ambra.giorgetti@rd.nestle.com for enrollment information.
Where is the NCT07242833 trial being conducted?
This trial is being conducted at Lausanne, Switzerland.
Who is sponsoring the NCT07242833 clinical trial?
NCT07242833 is sponsored by Société des Produits Nestlé (SPN). The principal investigator is Carolina Stambolsky, MD at Nestlé Research. The trial plans to enroll 60 participants.