NCT07263113 Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study
| NCT ID | NCT07263113 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Nantes University Hospital |
| Condition | Periodontis |
| Study Type | INTERVENTIONAL |
| Enrollment | 206 participants |
| Start Date | 2026-04-10 |
| Primary Completion | 2027-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 206 participants in total. It began in 2026-04-10 with a primary completion date of 2027-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways. The PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.
Eligibility Criteria
Inclusion Criteria: * Age 40-69 years * Minimum of 12 teeth (3 per quadrant) * Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium Exclusion Criteria: * Patients diagnosed with diabetes, * Patients diagnosed with hypertension or with a history of severe cardiovascular disease, * Patients diagnosed with familial hypercholesterolaemia, * Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results, * Patients with a BMI ≥ 30 kg/m², * Patients who have previously undergone periodontal treatment, * Patients who consume more than 2 units of alcohol per day, * Patients who refuse to participate in the study, * Minors and patients under the age of 40, * Adult patients under legal protection (guardianship, curatorship), * Patients deprived of their liberty, * Pregnant or breastfeeding women, * Patients not affiliated with a health insurance scheme (AME) * Patients already included in another interventional study
Frequently Asked Questions
Who can join the NCT07263113 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, up to 69 Years, studying Periodontis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07263113 currently recruiting?
Yes, NCT07263113 is actively recruiting participants. Visit ClinicalTrials.gov or contact Nantes University Hospital to inquire about joining.
Where is the NCT07263113 trial being conducted?
This trial is being conducted at Nantes, France.
Who is sponsoring the NCT07263113 clinical trial?
NCT07263113 is sponsored by Nantes University Hospital. The trial plans to enroll 206 participants.