NCT06634017 Evaluation of Effect of Platelet-Rich Fibrin on Orthodontic Tooth Movement: a Split Mouth Randomised Controlled Trial
| NCT ID | NCT06634017 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Dow University of Health Sciences |
| Condition | Rate of Tooth Movement in Orthodontic Patients |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2024-04-25 |
| Primary Completion | 2025-04-24 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 15 participants in total. It began in 2024-04-25 with a primary completion date of 2025-04-24.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
it is a randomized control trial and aims at investigating the effects of PRF on rate of tooth movement and root length to be tested on larger sample size of pakistani population
Eligibility Criteria
Inclusion Criteria: * Patients who give written consent to participate in the research * Orthodontic patients with good oral hygiene * Patients with periodontal probing depths≤3 mm with no bone loss * Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction * Patients treated with canine retraction utilizing maximum anchorage in the maxillary arch from trans-palatal arch anchorage device * Patients with mild to moderate crowding in maxillary arch * Patients with no previous history of orthodontic treatment Exclusion Criteria: * patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded. Other exclusion criteria will be patients with hypodontia, impacted/ectopic canines, extracted first molars, and patients who may discontinue the trial with or without assigning any reasons and those not consenting to participate in the research.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06634017 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Rate of Tooth Movement in Orthodontic Patients. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06634017 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT06634017 currently recruiting?
Yes, NCT06634017 is actively recruiting participants. Contact the research team at fahad.iqbal@duhs.edu.pk for enrollment information.
Where is the NCT06634017 trial being conducted?
This trial is being conducted at Karachi, Pakistan.
Who is sponsoring the NCT06634017 clinical trial?
NCT06634017 is sponsored by Dow University of Health Sciences. The trial plans to enroll 15 participants.