NCT07531901 Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid
| NCT ID | NCT07531901 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Montana |
| Condition | Cough Reflex Sensitivity |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2026-06-05 |
| Primary Completion | 2027-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2026-06-05 with a primary completion date of 2027-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.
Eligibility Criteria
Inclusion Criteria: * Healthy adults at least 18 years of age * Consent to audio/video recording of the research sessions for research purposes * Spirometry testing results obtained by study team on same day of first testing session with FEV1/FVC ratio and FEV1 percent predicted values of at least 0.70 Exclusion Criteria: * Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session) * Smoking of any substance in the last six months * Diagnosed or suspected pulmonary disease (e.g., asthma, COPD) * History of chronic cough * History of head or neck cancer * History of neurological disease (e.g., cerebrovascular accident) * History of dysphagia (swallowing difficulty) * Current complaint of a voice problem * Current upper respiratory infection
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07531901 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 89 Years, studying Cough Reflex Sensitivity. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07531901 currently recruiting?
Yes, NCT07531901 is actively recruiting participants. Contact the research team at jane.salois@umontana.edu for enrollment information.
Where is the NCT07531901 trial being conducted?
This trial is being conducted at Missoula, United States.
Who is sponsoring the NCT07531901 clinical trial?
NCT07531901 is sponsored by University of Montana. The trial plans to enroll 10 participants.