Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia
Trial Parameters
Brief Summary
This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory performance. iTBS (active or sham) will be administered, then the oscillatory activity of DLPFC and working memory performance will be reassessed. The overarching goal is to determine whether iTBS can acutely enhance the oscillatory activity of the DLPFC and to evaluate the relationship between changes in the DLPFC and working memory performance.
Eligibility Criteria
Inclusion Criteria: 1. ages 18-40 years 2. DSM diagnoses of Schizophrenia Spectrum Axis I disorders 3. a duration of less than three years from beginning of psychosis, defined by report of symptoms and/or history of treatment, based on clinical guidelines employed in our UPMC psychoses clinics in Pittsburgh. Exclusion Criteria: 1. DSM intellectual developmental disorder 2. significant head injury 3. medical illness affecting brain structure or function 4. significant neurologic disorder (e.g. seizure disorder) 5. personal history or family history of epilepsy 6. inability to provide informed consent 7. concussion with loss of consciousness (LOC) greater than 10 minutes 8. history of electroconvulsive therapy 9. diabetes with associated seizures, loss of sensation/weakness in arms or legs, or momentary LOC 10. pregnancy or postpartum (\<6 weeks after delivery or miscarriage), as determined by self-report 11. a psychotic illness with a temporal relation to substance use or head injury. 1