Effects of Physical Activity and Fitness, Cardiovascular- and Psychosocial Health on Medically Assisted Reproduction
Trial Parameters
Brief Summary
This prospective observational study aims to investigate the association between physical activity and clinical pregnancy rates in women undergoing medically assisted reproduction. Additionally, it evaluates how cardiorespiratory fitness, cardiovascular health, psychosocial factors, sleep quality, stress, and cognitive function relate to reproductive outcomes.
Eligibility Criteria
Inclusion Criteria: * Voluntary written informed consent of the participant has been obtained prior to any screening procedures * Age 18-43 * Planning to undergo MAR (eg, IUI, IVF, ICSI) - Physically able to cycle for cardiopulmonary exercise testing (CPET) Exclusion Criteria: * Any reduction in general state of health preventing from performing hormonal stimulation for MAR * Absolute and relative contraindications for cardiopulmonary exercise testing (CPET) - No pregnancy at initial screening - Current illicit drug abuse including daily marijuana and CBD consumption (alcohol ≤2 drinks per day allowed) * Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease) * Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2) * Known liver cirrhosis or other severe liver impairment * Uncontrolled dysthyroidism * Uncontrolled hypertension * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorde