NCT07317830 Effects of Different Vitamin D3 Formulations in Vitamin D-Deficient Adults
| NCT ID | NCT07317830 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Center for Health Sciences, Serbia |
| Condition | Vitamin D Deficiency |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-12-15 |
| Primary Completion | 2026-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2025-12-15 with a primary completion date of 2026-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled superiority pilot trial will evaluate the efficacy of two vitamin D3 formulations administered over eight weeks in adults with subclinical or clinical vitamin D deficiency. The study will compare changes in serum 25-hydroxyvitamin D concentrations between formulations, as well as the proportion of participants who will achieve vitamin D sufficiency. Both formulations are expected to improve vitamin D status, with the hypothesis that one formulation will demonstrate superior bioavailability, resulting in greater and faster increases in circulating 25-hydroxyvitamin D. The findings will provide preliminary evidence to inform formulation selection and dosing strategies for correcting vitamin D deficiency and will support the design of larger, confirmatory trials.
Eligibility Criteria
Inclusion Criteria: * Adults aged 18 years and over * Serum 25(OH)D \< 75 nmol/L * BMI 18.5 - 29.9 kg/m2 * Free of clinically significant acute disorders and severe chronic diseases * No planned travel to high-UV destinations or tanning bed use during the trial * Willing to avoid non-study vitamin D supplements * Able to give written informed consent and comply with study visits * Submitted informed consent Exclusion Criteria: * Pregnancy of breast feeding * Underweight or obesity * History of any dietary supplement use within 8 weeks before screening * Medications that materially alter vitamin D metabolism or calcium balance * Subjects with a history of medicine or alcohol abuse * Abnormal values for lab clinical chemistry (\> 2 SD) * Unwillingness to return for follow-up analysis * Participation in other clinical trials within 60 days prior to screening
Contact & Investigator
Sergej Ostojic, MD, PhD
STUDY CHAIR
University of California, Los Angeles
Frequently Asked Questions
Who can join the NCT07317830 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Vitamin D Deficiency. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07317830 currently recruiting?
Yes, NCT07317830 is actively recruiting participants. Contact the research team at sergej.ostojic@chess.edu.rs for enrollment information.
Where is the NCT07317830 trial being conducted?
This trial is being conducted at Belgrade, Serbia.
Who is sponsoring the NCT07317830 clinical trial?
NCT07317830 is sponsored by Center for Health Sciences, Serbia. The principal investigator is Sergej Ostojic, MD, PhD at University of California, Los Angeles. The trial plans to enroll 20 participants.