NCT07368621 Effectiveness of Connective Tissue Graft With and Without Leukocyte Platelet Rich Fibrin on Peri-implant Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype: A Randomized Controlled Clinical Trial
| NCT ID | NCT07368621 |
| Status | Recruiting |
| Phase | — |
| Sponsor | British University In Egypt |
| Condition | Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype |
| Study Type | INTERVENTIONAL |
| Enrollment | 38 participants |
| Start Date | 2026-01-16 |
| Primary Completion | 2026-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 38 participants in total. It began in 2026-01-16 with a primary completion date of 2026-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A stable soft and hard tissues around Osseo-integrated implants are very crucial. Soft tissue thickness around implants is crucial as it prevents peri-implant bone loss and enhance the esthetic outcomes. The treatment of thin tissue phenotype should be improved as the thin tissue phenotype will lead to plaque accumulation. There are some techniques that can increase the thickness of the peri-implant mucosa including connective tissue graft, platelet- rich fibrin and xenogeneic collagen matrix .Leukocyte and Platelet rich fibrin is a second generation platelet concentrate that was introduced by choukroun et al in 2001 after platelet rich plasma. PRF is the first source of autogenous blood derived growth factors harvested without the use of anticoagulants5. It contains various growth factors that are believed to contribute to periodontal regeneration. It promotes neovascularization and accelerated wound closing
Eligibility Criteria
Inclusion Criteria: * 1\. Patients between 18-60 years. 2. With thin gingival phenotype with a peri-implant mucosal thickness of less than 2mm28. With single missing tooth in the incisor, canine and premolar area. With the presence of two natural adjacent teeth and to not have a bone augmentation procedure before or during the dental implant. 3\. Patient consent approval and signing 4. Medically free patients 5. Patients with good oral hygiene 6. Patients free from untreated periodontal disease Exclusion Criteria: * 1\. Smokers 2. Psychological problem 3. Pregnancy 4. Systemic disease 5. Poor oral hygiene 6. Patients who previously received radiation therapy of the jaws 7. Patients taking medications that affect healing.
Frequently Asked Questions
Who can join the NCT07368621 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07368621 currently recruiting?
Yes, NCT07368621 is actively recruiting participants. Visit ClinicalTrials.gov or contact British University In Egypt to inquire about joining.
Where is the NCT07368621 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07368621 clinical trial?
NCT07368621 is sponsored by British University In Egypt. The trial plans to enroll 38 participants.