NCT07580144 Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients
| NCT ID | NCT07580144 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Konya Meram State Hospital |
| Condition | Sarcopenia |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-05-13 |
| Primary Completion | 2026-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2026-05-13 with a primary completion date of 2026-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.
Eligibility Criteria
Inclusion Criteria: * Scheduled to undergo elective surgery under general anesthesia requiring endotracheal intubation * Planned use of rocuronium for neuromuscular blockade * Quantitative neuromuscular monitoring planned during anesthesia * American Society of Anesthesiologists physical status I-III * Ability to provide written informed consent * Completion of preoperative frailty and sarcopenia assessment Exclusion Criteria: * Emergency surgery * Known neuromuscular disease * History of allergy or contraindication to rocuronium, sugammadex * Severe hepatic insufficiency * Severe renal insufficiency * Use of drugs known to significantly affect neuromuscular transmission * Preoperative mechanical ventilation or intensive care unit admission * Inability to perform a frailty or sarcopenia assessment * Patients in whom quantitative neuromuscular monitoring cannot be properly performed * Refusal to participate in the study
Contact & Investigator
Betül Kozanhan, M.D.
PRINCIPAL INVESTIGATOR
SBÜ Konya EAH
Frequently Asked Questions
Who can join the NCT07580144 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, up to 80 Years, studying Sarcopenia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07580144 currently recruiting?
Yes, NCT07580144 is actively recruiting participants. Contact the research team at betulkozanhan@gmail.com for enrollment information.
Where is the NCT07580144 trial being conducted?
This trial is being conducted at Konya, Turkey (Türkiye).
Who is sponsoring the NCT07580144 clinical trial?
NCT07580144 is sponsored by Konya Meram State Hospital. The principal investigator is Betül Kozanhan, M.D. at SBÜ Konya EAH. The trial plans to enroll 100 participants.