NCT06053229 Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization
| NCT ID | NCT06053229 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Brigham Young University |
| Condition | Massage Therapy |
| Study Type | INTERVENTIONAL |
| Enrollment | 36 participants |
| Start Date | 2023-03-01 |
| Primary Completion | 2024-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 36 participants in total. It began in 2023-03-01 with a primary completion date of 2024-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested: Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry. Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow. Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.
Eligibility Criteria
Inclusion Criteria: * 18-50 years old (women are pre-menopausal). We will exclude individuals over the age of 50 because the adaptive capability of skeletal muscle fundamentally changes with older age, and the risk from disuse increases. The findings of this study will help determine the risk benefit relationship of conducting a similar study in older individuals. * Stable levels of physical activity for at least 6 months * No history of lower extremity injury that would preclude their ability to perform knee extension exercise Exclusion Criteria: * Cigarette or marijuana smoker * Pregnant or planning to become pregnant within next month * Cardiovascular, metabolic disease or cognitive disease (e.g. Alzheimer's or mild cognitive impairment) * Taking prescribed medications (e.g. blood pressure medication) or anti-depressants * Habitual use of any type of massage or vibration on their thigh * Note that subjects who are mentally unable to understand the consenting process and provide informed consent will not be included in this study.
Contact & Investigator
Robert D Hyldahl, PhD
PRINCIPAL INVESTIGATOR
Brigham Young University
Frequently Asked Questions
Who can join the NCT06053229 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Massage Therapy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06053229 currently recruiting?
Yes, NCT06053229 is actively recruiting participants. Contact the research team at robhyldahl@byu.edu for enrollment information.
Where is the NCT06053229 trial being conducted?
This trial is being conducted at Provo, United States.
Who is sponsoring the NCT06053229 clinical trial?
NCT06053229 is sponsored by Brigham Young University. The principal investigator is Robert D Hyldahl, PhD at Brigham Young University. The trial plans to enroll 36 participants.