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Recruiting NCT06965335

NCT06965335 Early-Onset Colorectal Cancer: An Observational Retrospective and Prospective Multicenter Study

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Clinical Trial Summary
NCT ID NCT06965335
Status Recruiting
Phase
Sponsor Niguarda Hospital
Condition Colo-rectal Cancer
Study Type OBSERVATIONAL
Enrollment 20 participants
Start Date 2024-04-17
Primary Completion 2026-12-31

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age 40 Years
Study Type OBSERVATIONAL
Interventions
BIOLOGICAL STUDY aiming at describing clinicophatological features of EO-CRC vs SO-CRC

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 20 participants in total. It began in 2024-04-17 with a primary completion date of 2026-12-31.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

Observational, retrospective and prospective multicentric Italian study of patients diagnosed with colorectal cancer between age 18-40, aiming at underpinning the biology of vEO-CRC, including colibactin as well as a broader proteo-genomic characterization, to identify potential new therapeutic targets specifically directed to this peculiar subset of patients.

Eligibility Criteria

1. Patients with diagnosis of colorectal cancer (vEO-CRC: 18-40 years of age), or SO-CRC diagnosed later than age 60; 2. Informed consent signature from alivepatient; 3. Availability of formalin-fixed paraffin embedded (FFPE) tumor samples (5 FFPE 4uM thick slides and 10 FFPE 10 uM thick slides) and/or fresh tumor tissue retrieved from a biopsy or surgical procedure performed as per clinical standard of care.

Contact & Investigator

Central Contact

Salvatore Siena, MD

✉ salvatore.siena@ospedaleniguarda.it

📞 +39 02 6444

Frequently Asked Questions

Who can join the NCT06965335 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, up to 40 Years, studying Colo-rectal Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT06965335 currently recruiting?

Yes, NCT06965335 is actively recruiting participants. Contact the research team at salvatore.siena@ospedaleniguarda.it for enrollment information.

Where is the NCT06965335 trial being conducted?

This trial is being conducted at Milan, Italy.

Who is sponsoring the NCT06965335 clinical trial?

NCT06965335 is sponsored by Niguarda Hospital. The trial plans to enroll 20 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology