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Recruiting EARLY_Phase 1 NCT06520982
Early Neurovascular Adaptations in Aging Women
Trial Parameters
Condition Women
Sponsor University of Missouri-Columbia
Study Type INTERVENTIONAL
Phase EARLY_Phase 1
Enrollment 64
Sex FEMALE
Min Age 18 Years
Max Age 70 Years
Start Date 2024-09-20
Completion 2027-06-30
All Conditions
Interventions
NorepinephrineIsoproterenolAcetylcholine
Brief Summary
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Eligibility Criteria
Inclusion Criteria: * Assigned female at birth (AFAB) * 18-70 years of age Exclusion Criteria: * Assigned male at birth (AMAB) * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Taking medications known to affect metabolic, autonomic, and/or respiratory function * Oral hormonal contraception in last 6 month * History of hormone replacement therapy * History of hyster- or oophor-ectomy * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Chronic disease * Blood pressure ≥140/90 mmHg * Communication barriers
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