NCT06482138 Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
| NCT ID | NCT06482138 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universitaire Ziekenhuizen KU Leuven |
| Condition | Covid19 |
| Study Type | INTERVENTIONAL |
| Enrollment | 240 participants |
| Start Date | 2024-01-24 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 240 participants in total. It began in 2024-01-24 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.
Eligibility Criteria
Inclusion Criteria: * Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10 * Control group: No OD (TDI-score \>30.5.) Exclusion Criteria: * Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations * Use of anticoagulation therapy * Allergy to local anesthetics
Contact & Investigator
Laura van Gerven
PRINCIPAL INVESTIGATOR
UZ/KU Leuven
Frequently Asked Questions
Who can join the NCT06482138 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Covid19. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06482138 currently recruiting?
Yes, NCT06482138 is actively recruiting participants. Contact the research team at laura.vangerven@uzleuven.be for enrollment information.
Where is the NCT06482138 trial being conducted?
This trial is being conducted at Brussels, Belgium, Leuven, Belgium, Bruges, Belgium, Dresden, Germany and 3 additional locations.
Who is sponsoring the NCT06482138 clinical trial?
NCT06482138 is sponsored by Universitaire Ziekenhuizen KU Leuven. The principal investigator is Laura van Gerven at UZ/KU Leuven. The trial plans to enroll 240 participants.
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