NCT07109739 Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
| NCT ID | NCT07109739 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Minnesota |
| Condition | Systolic Hypertension |
| Study Type | INTERVENTIONAL |
| Enrollment | 144 participants |
| Start Date | 2025-10-24 |
| Primary Completion | 2027-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 144 participants in total. It began in 2025-10-24 with a primary completion date of 2027-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years * Resting SBP ≥120 mmHg as measured during screening 1 \& 2 * Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis. * No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax) * Language: English-speaking, with ability to comprehend study materials and instructions. * Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit. * Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year). Exclusion Criteria: * Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum). * Recent abdominal surgery or presence of an abdominal hernia. * Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea. * Ruptured eardrum or any other condition of the ear. * Markedly elevated left ventricular end-diastolic volume and pressure. * Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition). * Female-Specific: Pregnant or planning to become pregnant during the study period. * Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).
Contact & Investigator
Daniel Craighead, PhD
PRINCIPAL INVESTIGATOR
University of Minnesota
Frequently Asked Questions
Who can join the NCT07109739 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Systolic Hypertension. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07109739 currently recruiting?
Yes, NCT07109739 is actively recruiting participants. Contact the research team at lewi1241@umn.edu for enrollment information.
Where is the NCT07109739 trial being conducted?
This trial is being conducted at Minneapolis, United States.
Who is sponsoring the NCT07109739 clinical trial?
NCT07109739 is sponsored by University of Minnesota. The principal investigator is Daniel Craighead, PhD at University of Minnesota. The trial plans to enroll 144 participants.