Dexmedetomidine and Magnesium Sulfate in the Reduction Cognitive Dysfunction in Geriatrics
Trial Parameters
Brief Summary
Magnesium sulfate is considered a neuroprotective drug and has been studied in various applications. Recently, it has drawn the attention of anesthesiologists, resulting in numerous publications about its role in anesthesiology. Magnesium sulfate is suggested to exert its neuroprotective effect by preventing excitotoxicity. in the clinical setting, intraoperative magnesium sulfate attenuated POCD. Furthermore, postoperative emergence agitation was significantly reduced in pediatric patients who received intraoperative magnesium sulfate during adenotonsillectomy. The aim of this study The aim of this work is to compare the protective effect of intraoperative dexmedetomidine with magnesium sulfate against developing POCD and to study their effect on serum level of CRP; the marker of neuronal degeneration.
Eligibility Criteria
Inclusion Criteria: * ASA physical status I, II and ⅠⅠⅠ * patients undergoing open abdominal surgery under general anesthesia Exclusion Criteria: * Elderly patients with preoperative MoCA Score below 26. * Operation time more than 4 hours to prevent excessive dosage of magnesium sulfate. * BMI \> 35 kg m-2