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Recruiting NCT04857528

NCT04857528 Detecting HPV DNA in Anal and Cervical Cancers

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Clinical Trial Summary
NCT ID NCT04857528
Status Recruiting
Phase
Sponsor University of Chicago
Condition Cervical Cancer
Study Type OBSERVATIONAL
Enrollment 20 participants
Start Date 2020-10-06
Primary Completion 2027-11-15

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
Radiation Treatment With or Without ChemotherapyBlood Sample CollectionHPV Genotyping (HPV DNA Test)

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 20 participants in total. It began in 2020-10-06 with a primary completion date of 2027-11-15.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

This is a research study for individuals who have cancer associated with human papillomavirus (HPV) and are being treated with radiation as part of standard care for their cancer. Doctors leading this study will use blood tests to find out if they can detect the HPV virus in the blood of study participants before, during, and after radiation treatment. They will also collect blood and archival tumor tissue (from a previous biopsy) to perform other tests in the future that could provide more information about HPV-associated cancers and how they respond to treatment. Participation in this study will last approximately 2 years.

Eligibility Criteria

Inclusion Criteria: * Stage I-III anal cancer or stage I-IVA cervical cancer that is p16+ based on immunohistochemistry. * Age ≥ 18 years * Planned to undergo radiation therapy as definitive treatment, with or without concurrent systemic therapy Exclusion Criteria: * Anal carcinoma not associated with HPV-16, 18, 31, 33, or 35 will be removed from the * Planned to undergo radiation therapy as an adjuvant or post-operative therapy

Contact & Investigator

Central Contact

Christina Son, MD

✉ cson@radonc.uchicago.edu

📞 773-702-6870

Principal Investigator

Christina Son, MD

PRINCIPAL INVESTIGATOR

University of Chicago

Frequently Asked Questions

Who can join the NCT04857528 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Cervical Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT04857528 currently recruiting?

Yes, NCT04857528 is actively recruiting participants. Contact the research team at cson@radonc.uchicago.edu for enrollment information.

Where is the NCT04857528 trial being conducted?

This trial is being conducted at Chicago, United States, Chicago, United States.

Who is sponsoring the NCT04857528 clinical trial?

NCT04857528 is sponsored by University of Chicago. The principal investigator is Christina Son, MD at University of Chicago. The trial plans to enroll 20 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology