NCT06329908 DC Combined With ICIs in the Treatment of Advanced Lung Cancer Resistant to ICIs
| NCT ID | NCT06329908 |
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Sponsor | Zhen-Yu Ding |
| Condition | Lung Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2023-09-27 |
| Primary Completion | 2024-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 20 participants in total. It began in 2023-09-27 with a primary completion date of 2024-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a single-center, single-arm, prospective clinical trial to investigate the safety and efficacy of Neo-DCVac combined with ICIs in the treatment of advanced lung cancer resistant to ICIs.
Eligibility Criteria
Inclusion Criteria: * Aged 18-85 years. * ECOG score was 0-2. * Histological or cytological diagnosis confirmed non-small cell lung cancer, which was staged IIIB-IV according to AJCC version 8. * Patients have received first-line chemotherapy combined with ICIs (PD1/PD-L1, ICIs type is not limited) and developed drug resistance. * Normal function of major organs, that is, meeting the following criteria: a) blood routine examination (hematopoietic growth factors and blood transfusion were not used within 7 days): granulocyte count ≥ 1.5 × 109/L, platelet count ≥ 80 × 109/L, hemoglobin ≥ 80 g/L; b) biochemical examination: total bilirubin ≤ 1.5 × ULN (upper limit of normal); serum alanine aminotransferase (ALT) or serum aspartate aminotransferase (AST) ≤ 2.5 × ULN; creatinine clearance ≥ 60 mL/min (Cockcroft-Gault formula); c) coagulation function: INR or PT ≤ 1.5 × ULN (upper limit of normal), if the subject is receiving anticoagulant therapy, as long as PT is in the range proposed by anticoagulant drugs; d) urine routine examination: urine routine examination urine protein ≥ 2 +, 24-hour urine protein quantitative examination should be performed, such as quantitative urine protein ≤ 1 g/24 h. * Female subjects of childbearing age or male subjects with sexual partners of childbearing age should take effective contraceptive measures throughout the treatment period and 6 months before and after the treatment period. * Subjects voluntarily participate in the study and sign the informed consent form Exclusion Criteria: * The pathological type is mixed type, containing small cell carcinoma or other types of components. * with the blood-borne infectious disease HIV. * History of mental disorder, drug abuse and drug abuse. * Any other malignancy (except completely cured cervical carcinoma in situ or basal cell or squamous cell skin cancer) within 3 years. * Accompanied by other immune diseases, or long-term use of immunosuppressive agents or hormones. * Any unstable systemic disease (including active uncontrolled gastrointestinal ulcers, gastric obstruction, bleeding risk or coagulopathy, active infection, for subjects with hepatitis B, anti-hepatitis B 11 virus treatment is required during study treatment, active hepatitis C subjects (HCV antibody positive and HCV- RNA levels above the lower limit of detection, grade IV hypertension, unstable angina pectoris, congestive heart failure, myocarditis, unstable cerebrovascular disease, thrombotic disease, liver, kidney, uncontrolled metabolic disease or unhealed fractures, wounds as judged by the surgeon). * Presence of active central nervous system (CNS) metastases; subjects with previously treated brain metastases (e.g., surgery, radiotherapy, hormone therapy) are allowed if clinically stable for at least two weeks after treatment from the first dose of study drug and corticosteroids are discontinued 7 days before study drug administration; untreated, asymptomatic subjects with brain metastases (i.e., no neurological symptoms, no need for corticosteroids, no significant edema around the brain metastases) can be enrolled. * Any anti-tumor therapy including chemotherapy, radiotherapy, and targeted therapy within 3 weeks prior to the first dose of study drug. * Presence of pleural effusion, pericardial effusion, or ascites with clinical symptoms or requiring drainage. * Previous use of anti-tumor vaccines, live vaccines within 30 days. * Patients are difficult to communicate or to follow up for a long time. Pregnant or lactating women. * Current or planned participation in other clinical trials. * Dr. finds other unsuitable situations
Contact & Investigator
Qing Li, MD
STUDY CHAIR
West China Hospital
Frequently Asked Questions
Who can join the NCT06329908 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06329908 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT06329908 currently recruiting?
Yes, NCT06329908 is actively recruiting participants. Contact the research team at dingzhenyu@scu.edu.cn for enrollment information.
Where is the NCT06329908 trial being conducted?
This trial is being conducted at Chengdu, China.
Who is sponsoring the NCT06329908 clinical trial?
NCT06329908 is sponsored by Zhen-Yu Ding. The principal investigator is Qing Li, MD at West China Hospital. The trial plans to enroll 20 participants.
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