NCT07378774 Constraint Induced Movement Therapy and Bilateral Training in Chronic Stroke
| NCT ID | NCT07378774 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zikra Azhar |
| Condition | Chronic Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 112 participants |
| Start Date | 2026-02-05 |
| Primary Completion | 2026-04-05 |
Eligibility & Interventions
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 112 participants in total. It began in 2026-02-05 with a primary completion date of 2026-04-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Stroke is a leading cause of long-term disability, with upper limb spasticity and impaired hand function being common problems in the chronic phase. These impairments significantly affect independence in activities of daily living and overall quality of life. Constraint-Induced Movement Therapy (CIMT) and Bilateral Training (BT) are two widely used neurorehabilitation approaches aimed at improving upper limb motor recovery after stroke; however, evidence comparing their effectiveness on wrist spasticity and hand function in chronic stroke patients remains limited. This single-blinded randomized controlled trial aims to compare the effects of Constraint-Induced Movement Therapy combined with Functional Electrical Stimulation (FES) versus Bilateral Training combined with Functional Electrical Stimulation on wrist spasticity and hand function in patients with chronic stroke. A total of 94 participants diagnosed with chronic stroke will be randomly allocated into two groups. Group A will receive CIMT with FES, while Group B will receive Bilateral Training with FES. Both interventions will be administered three times per week for eight weeks. Outcome measures will include wrist spasticity assessed using the Modified Ashworth Scale (MAS) and upper limb motor function assessed using the Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and the Chedoke Arm and Hand Activity Inventory (CAHAI). Assessments will be conducted at baseline and after completion of the intervention period. The findings of this study are expected to provide evidence on the comparative effectiveness of CIMT and Bilateral Training in improving wrist spasticity and hand function, thereby assisting clinicians in selecting optimal rehabilitation strategies for chronic stroke patients.
Eligibility Criteria
Inclusion Criteria: * Patients diagnosed with stroke in chronic phase. Patients with normal cognition (MMS 21 and above) Both male and female patients will be included. Adult patients will be included. (age 18-65) Participants with spasticity score of 2 or less on MAS. Exclusion Criteria: * Acute and other neurological and musculoskeletal conditions e.g. Parkinson's, multiple sclerosis. Patients who do not agree to treatment.
Contact & Investigator
Zikra Azhar, MSPTN
PRINCIPAL INVESTIGATOR
The University of Lahore, Lahore
Frequently Asked Questions
Who can join the NCT07378774 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Chronic Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07378774 currently recruiting?
Yes, NCT07378774 is actively recruiting participants. Contact the research team at zikraazhar4@gmail.com for enrollment information.
Where is the NCT07378774 trial being conducted?
This trial is being conducted at Lahore, Pakistan.
Who is sponsoring the NCT07378774 clinical trial?
NCT07378774 is sponsored by Zikra Azhar. The principal investigator is Zikra Azhar, MSPTN at The University of Lahore, Lahore. The trial plans to enroll 112 participants.
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