NCT07556536 Comparison of Serratus Intercostal Plane Blcok With Erector Spinae Plane Block for Open Nephrectomy
| NCT ID | NCT07556536 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fayoum University Hospital |
| Condition | Post Operative Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 132 participants |
| Start Date | 2026-04-10 |
| Primary Completion | 2027-03-01 |
Eligibility & Interventions
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 132 participants in total. It began in 2026-04-10 with a primary completion date of 2027-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Effective postoperative pain management following open nephrectomy remains a significant clinical challenge. Inadequate pain control after this procedure may lead to impaired respiratory function, delayed mobilization, prolonged hospital stay, increased opioid consumption, and a higher incidence of postoperative complications. Therefore, optimizing postoperative analgesia while minimizing opioid-related adverse effects is a key objective in perioperative care for patients undergoing open nephrectomy Traditionally, postoperative pain following open nephrectomy has been managed using systemic opioids, epidural analgesia, or paravertebral blocks. Ultrasound-guided fascial plane blocks have emerged as valuable alternatives in modern regional anesthesia due to their simplicity, safety profile, and effectiveness. Among these techniques, the erector spinae plane (ESP) block has gained widespread popularity. This block has been shown to provide effective analgesia for thoracic, abdominal, and urologic surgeries, including nephrectomy The ultrasound-guided serratus intercostal plane block (SIPB) is a more recently described regional anesthetic technique targeting the lateral cutaneous branches of the intercostal nerves by injecting local anesthetic between the serratus anterior muscle and the intercostal muscles or ribs By blocking these nerves, SIPB provides analgesia to the lateral thoracic wall and upper abdominal regions, which are particularly relevant to flank incisions used in open nephrectomy. Patients will be randomly allocated into two equal groups. Patients in group (S) will receive serratus intercostal plane block and those in group (E) will receive Erector spinae plane block . Both of these blocks will be performed after induction of general anaesthesia by an experienced anaesthesiologist The aim of this study is to to compare the analgesic efficacy of ultrasound-guided serratus intercostal plane block and erector spinae plane block in patients undergoing open nephrectomy.
Eligibility Criteria
Inclusion Criteria: 1. Patients scheduled for elective open nephrectomy under general anesthesia via flank incision . 2. Adult patients aged 18-65 years. 3. Patients with an American Society of Anesthesiologists (ASA) physical status I to III. Exclusion Criteria: 1. Patient refusal. 2. Allergy to local anesthetics and patient with infection at the injection site of block. 3. Coagulation disorders or ongoing anticoagulant therapy. 4. Patients receiving opioids for chronic analgesic therapy (cancer, addiction). 5. Cognitive impairment preventing pain scoring. 6. Neurological or psychiatric disorders affecting pain assessment.
Contact & Investigator
Mohamed A Hamed, MD
PRINCIPAL INVESTIGATOR
faculty of medicine, fayoum university
Frequently Asked Questions
Who can join the NCT07556536 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Post Operative Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07556536 currently recruiting?
Yes, NCT07556536 is actively recruiting participants. Contact the research team at hm163@fayoum.edu.eg for enrollment information.
Where is the NCT07556536 trial being conducted?
This trial is being conducted at Al Fayyum, Egypt.
Who is sponsoring the NCT07556536 clinical trial?
NCT07556536 is sponsored by Fayoum University Hospital. The principal investigator is Mohamed A Hamed, MD at faculty of medicine, fayoum university. The trial plans to enroll 132 participants.