NCT05606809 Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest
| NCT ID | NCT05606809 |
| Status | Recruiting |
| Phase | — |
| Sponsor | AfterROSC |
| Condition | Cardiac Arrest |
| Study Type | OBSERVATIONAL |
| Enrollment | 4,500 participants |
| Start Date | 2022-11-02 |
| Primary Completion | 2027-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 4,500 participants in total. It began in 2022-11-02 with a primary completion date of 2027-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.
Eligibility Criteria
Inclusion Criteria: * all adult patients, major, admitted to intensive care after cardiac arrest (after both in and out-of hospital cardiac arrest), * comatose (defined by Glasgow score ≤ 8) on admission, Exclusion Criteria: * cardiac arrest occurring intra-hospital, * minor patient, * major patient under guardianship, * protected persons, * prior inclusion in the study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05606809 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Cardiac Arrest. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05606809 currently recruiting?
Yes, NCT05606809 is actively recruiting participants. Contact the research team at jeanbaptiste.lascarrou@chu-nantes.fr for enrollment information.
Where is the NCT05606809 trial being conducted?
This trial is being conducted at Nantes, France, Massy, France, Neuilly-sur-Seine, France, Paris, France and 1 additional location.
Who is sponsoring the NCT05606809 clinical trial?
NCT05606809 is sponsored by AfterROSC. The trial plans to enroll 4,500 participants.