Recruiting NCT06449989

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer

Trial Parameters

Condition Colorectal Cancer Metastatic

Sponsor Blokhin's Russian Cancer Research Center

Study Type OBSERVATIONAL

Phase N/A

Enrollment 30

Sex ALL

Min Age 18 Years

Max Age N/A

Start Date 2024-04-01

Completion 2027-09

All Conditions

Colorectal Cancer Metastatic Brain Metastases, Adult Ras (KRAS or NRAS) Gene Mutation BRAF Gene Mutation HER2 Gene Mutation MSI

Interventions

Tumor samples will be tested for mutation status of KRAS, NRAS, BRAF, HER2 and MSI

Brief Summary

GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study was conducted by post hoc analysis of pairs of samples of histological material with determination of the mutational status of genes KRAS, NRAS, BRAF, HER2 and MSI.

Eligibility Criteria

Inclusion Criteria: 1. Men and women over 18 years of age. 2. Histologically confirmed cancer of the colon or rectum. 3. Histologically confirmed metastatic lesion of the brain. 4. Neurosurgical resection for brain metastases of colorectal cancer. 5. Presence of paired tumor samples (both primary tumor and intracranial material). Exclusion Criteria: 1. Missing one sample from a pair of tumor samples. 2. Low quality or lack of tumor material for molecular genetic research.

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