Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults
Trial Parameters
Brief Summary
This randomized study will be conducted to compare the effect of a healthy beef-centric diet to a healthy U.S.-style dietary pattern on inflammation and other metabolic health outcomes in a metabolic syndrome and/or pre-diabetic population.
Eligibility Criteria
Inclusion Criteria: * Participant must be 18 - 64 years of age (inclusive) at the time of signing the informed consent. * Have a BMI range of 25.0 - 39.9 kg/m2 (inclusive). * In otherwise generally good health as determined by the investigator. * Have blood hs-CRP levels equal to or greater than 2.0 mg/L at screening. * Have the following conditions at screening: 1. Pre-diabetes (defined as an HbA1c of 5.7-6.4% \[inclusive\]), and/or 2. MetS, i.e., have 3 of the 5 following metabolic criteria: * A waist circumference of more than 40 inches (102 cm) in men and 35 inches (88 cm) in women * Serum triglycerides level of 150 mg/dL (1.7 mmol/L) or greater * Reduced HDL cholesterol, less than 40 mg/dL (1.0 mmol/L) in men or less than 50 mg/dL (1.3 mmol/L) in women * Elevated fasting glucose of 100 mg/dL (5.6 mmol/L) or greater * Blood pressure values of systolic 130 mmHg or higher or diastolic 85 mmHg or higher * Report low levels of physical activity, as defined by a "low" activity classific