NCT03542734 Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
| NCT ID | NCT03542734 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine |
| Condition | Cerebral Small Vessel Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,000 participants |
| Start Date | 2010-01-01 |
| Primary Completion | 2030-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,000 participants in total. It began in 2010-01-01 with a primary completion date of 2030-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage). The patients will receive neuropsychological testing, retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD and cognitive deficits.
Eligibility Criteria
Inclusion Criteria: * Adult (≥40y; no upper limit) * Free of known dementia or stroke (both cerebral infarction and hemorrhage) Exclusion Criteria: * Any MRI contraindications * Serious head injury (resulting to loss of consciousness) or received intracranial surgery * Suffering from cancer
Contact & Investigator
Frequently Asked Questions
Who can join the NCT03542734 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, studying Cerebral Small Vessel Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03542734 currently recruiting?
Yes, NCT03542734 is actively recruiting participants. Contact the research team at loumingxc@vip.sina.com for enrollment information.
Where is the NCT03542734 trial being conducted?
This trial is being conducted at Hangzhou, China.
Who is sponsoring the NCT03542734 clinical trial?
NCT03542734 is sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine. The trial plans to enroll 1,000 participants.