NCT07397858 Cognition and Behavior With Sham Accelerated TMS
| NCT ID | NCT07397858 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Davis |
| Condition | Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 25 participants |
| Start Date | 2026-04-11 |
| Primary Completion | 2027-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 25 participants in total. It began in 2026-04-11 with a primary completion date of 2027-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given. The main questions this study aims to answer are: 1. Do expectancy and treatment beliefs change during and after an accelerated sham TMS schedule? 2. Do these expectations influence mood, reward processing, or craving? 3. Does a more intensive schedule of sham sessions lead to different expectancy effects than a slower, once-daily schedule? Participants will: * Complete baseline clinical assessments and an MRI session * Undergo five days of accelerated sham TMS (no active brain stimulation is delivered) * Complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks
Eligibility Criteria
Inclusion Criteria: * English speaking * Able to provide informed consent (and assent if \< 18 years) * 15-25 years old * Slight-to-severe symptoms of depression Exclusion Criteria: * Past exposure to Transcranial Magnetic Stimulation * Unable to consent (due to medical condition, psychosis, substance use, etc) * Acute suicidal crisis or with active medical illness that would interfere with participation * Contraindications to receiving MRI as determined by screening questionnaires (Contraindications for MRI include metal in the body related to an injury or surgery, for example, surgical clips, metal fragments in the eyes, or piercings that cannot be removed. Subjects with braces or permanent retainers will not be scanned, because the effects on image signal are not well understood and may affect comparability between subjects and scan sites. Participants will be excluded for major neurological problems, such as seizure disorder, traumatic brain injury with loss of consciousness, or sensory problems that may impair task performance, such as blindness.) * Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies
Frequently Asked Questions
Who can join the NCT07397858 clinical trial?
This trial is open to participants of all sexes, aged 15 Years or older, up to 25 Years, studying Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07397858 currently recruiting?
Yes, NCT07397858 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of California, Davis to inquire about joining.
Where is the NCT07397858 trial being conducted?
This trial is being conducted at Sacramento, United States.
Who is sponsoring the NCT07397858 clinical trial?
NCT07397858 is sponsored by University of California, Davis. The trial plans to enroll 25 participants.
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