NCT07091877 Cocaine Cue-reactivity Incubation Study
| NCT ID | NCT07091877 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Icahn School of Medicine at Mount Sinai |
| Condition | Cocaine Use Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 252 participants |
| Start Date | 2024-12-15 |
| Primary Completion | 2028-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 252 participants in total. It began in 2024-12-15 with a primary completion date of 2028-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In this study, the research team proposes to longitudinally assess incubation of cue-reactivity, its reduction with cognitive reappraisal (CR; a self-regulation technique) and examine the impact of CR on clinical outcomes in individuals with cocaine use disorder (CUD). The primary objective is to use psychophysiological markers for tracking brain activity and behavior and changes therein with the use of CR during abstinence in CUD. The secondary objective is to examine whether brain and behavioral changes are associated with clinical outcomes in individuals with CUD. The primary endpoint is the time-related change in brain and behavioral indices with CR during abstinence in individuals with CUD. The secondary endpoint is the impact of CR-mediated changes on clinical outcomes of individuals with CUD. In this 5-yearlong study the research team will recruit 252 individuals seeking-treatment for CUD, 126 of whom will be randomly assigned to complete the Cognitive Reappraisal task repeatedly at 2 weeks, 1-2 months, 3 months, and 5 months after abstinence initiation (CR+ group), and the other 126 will be assigned to complete a Control task at the same time points (CR- group). All individuals between the ages of 18 and 65 years, irrespective of sex and sexual orientation will be recruited. Participation in the research study will be 5 sessions taking place (one at 2 weeks from screening, one at a month from screening, one at 3 months from screening, one at 5 months from screening, and one the month after the 5 month session) over the course of 6 months. The study will include EEG testing and will be administered multiple times over the course of 6 months. Participants will be randomized to one of the two groups; one group will get the Cognitive Reappraisal (CR+) intervention and the other group will get a Control intervention (CR-).
Eligibility Criteria
Inclusion Criteria: * Ability to understand and give informed consent * Age 18-65 * DSM-5 Diagnosis of CUD (Cocaine Use Disorder) * Have appropriate abstinence duration (i.e., \<2 months) at the first visit. * Must be seeking treatment for CUD (at the first visit) Exclusion Criteria: * DSM-5 diagnosis for other psychiatric illnesses (other than mood and anxiety disorders that are highly comorbid with substance use disorders) * Urine positive for any psychoactive drugs (e.g., cocaine, methamphetamine, cannabis, opiates, benzodiazepines, etc.) at baseline * Head trauma with loss of consciousness * History of neurological diseases, including seizures * Thick and/or non-removable hair braids that present difficulty for EEG electrode-scalp contact
Contact & Investigator
Muhammad A Parvaz, PhD
PRINCIPAL INVESTIGATOR
Icahn School of Medicine at Mount Sinai
Frequently Asked Questions
Who can join the NCT07091877 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Cocaine Use Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07091877 currently recruiting?
Yes, NCT07091877 is actively recruiting participants. Contact the research team at muhammad.parvaz@mssm.edu for enrollment information.
Where is the NCT07091877 trial being conducted?
This trial is being conducted at New York, United States.
Who is sponsoring the NCT07091877 clinical trial?
NCT07091877 is sponsored by Icahn School of Medicine at Mount Sinai. The principal investigator is Muhammad A Parvaz, PhD at Icahn School of Medicine at Mount Sinai. The trial plans to enroll 252 participants.