NCT07346378 Clinical Study on the Safety and Efficacy of Temporal Interference Stimulation in the Treatment of Post-Stroke Aphasia
| NCT ID | NCT07346378 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The First Affiliated Hospital of Anhui Medical University |
| Condition | Post-stroke Aphasia |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2027-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2025-12-01 with a primary completion date of 2027-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Neurological disorders encompass a wide variety of diseases, including congenital and neurodevelopmental disorders, cerebrovascular and neurodegenerative diseases, nervous system infections, neuroimmune diseases, neuromuscular or peripheral nervous system disorders, traumatic injuries, and tumor-related neurological conditions, with diverse symptomatic manifestations. The etiology, symptoms, and disease courses of these disorders vary significantly, severely impacting human health and social development, and have become a critical global public health issue. Some neurological disorders can lead to lifelong disability or high mortality rates, while others remain poorly understood, lacking effective treatments or cures. Post-stroke aphasia (PSA) is an acquired language impairment caused by ischemic or hemorrhagic injuries to the central nervous system. Its clinical manifestations are diverse, potentially affecting spontaneous speech, auditory comprehension, repetition, naming, reading, and writing abilities, among other aspects. Statistics indicate that over 16 million people worldwide suffer from stroke each year, with approximately 38% of survivors experiencing aphasia. The prognosis for this condition is concerning, as more than 40% of patients still exhibit significant language impairments one year after the stroke, with some even facing lifelong effects. The large patient population, significant communication barriers, and poor prognosis severely diminish patients' quality of life, significantly increasing their risk of emotional disorders such as depression and social isolation. This poses a substantial challenge to family caregiving and public health systems. Therefore, the development of non-invasive and effective novel therapeutic approaches holds substantial scientific and societal importance. Temporal interference stimulation (TI) technology represents a breakthrough in achieving non-invasive deep brain stimulation. This technology is based on the interference phenomenon, utilizing two pairs of surface electrodes to simultaneously apply sinusoidal wave stimuli at 2 kHz and 2.01 kHz. Two cortical regions are exposed to electric fields of 2 kHz or 2.01 kHz, and an interference electric field is generated in the brain region where these two fields overlap, with its envelope oscillating at 10 Hz. This technology has already been applied in the treatment of conditions such as depression, Parkinson's disease, and disorders of consciousness. The primary objective of this study is to explore the effects of TI intervention on deep brain regions, particularly on motor and non-motor related brain networks and functions in patients with neurological disorders, especially post-stroke aphasia. This research aims to provide a potential new approach for improving the clinical symptoms of these patients.
Eligibility Criteria
Inclusion Criteria: * Diagnosed with post-stroke aphasia; * Right-handed; * Native Chinese speaker with comprehension of Mandarin; * Aged 18-80 years; * Complete relevant assessment and imaging data; * Informed consent obtained from the patient and their family. Exclusion Criteria: * Cerebellar involvement in the stroke lesion, and incomplete scanning of cerebellar structures; * Severe dysarthria; * Concurrent epilepsy with occasional seizures; * Implanted pacemaker or deep brain stimulator; * History of brain tissue resection for prior lesions such as brain tumours or brain abscesses; * Other severe psychiatric disorders.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07346378 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Post-stroke Aphasia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07346378 currently recruiting?
Yes, NCT07346378 is actively recruiting participants. Contact the research team at zhanyuqian1998@163.com for enrollment information.
Where is the NCT07346378 trial being conducted?
This trial is being conducted at Hefei, China.
Who is sponsoring the NCT07346378 clinical trial?
NCT07346378 is sponsored by The First Affiliated Hospital of Anhui Medical University. The trial plans to enroll 40 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.