NCT05581030 CalPeg for Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
| NCT ID | NCT05581030 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | H. Lee Moffitt Cancer Center and Research Institute |
| Condition | Acute Lymphoblastic Leukemia |
| Study Type | INTERVENTIONAL |
| Enrollment | 7 participants |
| Start Date | 2023-05-01 |
| Primary Completion | 2026-10 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 7 participants in total. It began in 2023-05-01 with a primary completion date of 2026-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of the study is to evaluate the safety and tolerability of the study drug, calaspargase pegol, when given with multi-agent chemotherapy.
Eligibility Criteria
Inclusion Criteria: * Pathologically confirmed Philadelphia negative B- or T-cell acute lymphoblastic leukemia, with \>10% peripheral blood or bone marrow lymphoblasts at diagnosis. * Treatment and full recovery from arm 1A of the Hyper-CVAD regimen. * Be willing and able to provide written informed consent/assent for the trial. * Able to adhere to the study visit schedule and other protocol requirements. * Eastern Cooperative Oncology Group (ECOG) performance status 0-1. * Cardiac ejection fraction ≥ 50% by echocardiography or MUGA, as measured prior to arm 1A of Hyper-CVAD. * Serum bilirubin and creatinine \< 1.5x upper limit of normal (ULN). AST and ALT must be \<3x ULN. * Females of childbearing potential (FCBP) must have a negative serum pregnancy test at screening. A FCBP is considered when a sexually mature female: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months. * A FCBP must agree to use of two methods of highly effective non-hormonal contraception, be surgically sterile, or abstain from heterosexual activity for the course of the study through 3 monthsafter the last dose of study treatment. * Male subjects must agree to use an adequate method of contraception starting with the first dose of study therapy through 30 days after the last dose of study therapy. Men must agree to not donate sperm during and after the study for 3 months Exclusion Criteria: * Induction therapy with any regimen other than Hyper-CVAD 1A. * Diagnosis of L3 type Burkitt's lymphoma * Clinical evidence of active central nervous system (CNS) leukemia. * Any major surgery or radiation therapy within four weeks. * Diagnosis of Down Syndrome. * Any active infection requiring systemic therapy, including HIV, Hepatitis B, and/or Hepatitis C. * Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator (including but not limited to unstable angina, pre-existing liver disease, recurrent pancreatitis, uncontrolled diabetes, hypertriglyceridemia, pulmonary hypertension, or severeheart failure (New York Heart Association Class III-IV). * Recurrent thrombosis, or non-central venous catheter associated thrombosis within 3 months prior to enrollment. * Severe comorbid conditions for which life expectancy would be \<6 months. * Patients with active (uncontrolled, metastatic) second malignancies are excluded. * Is pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 3 months after the last dose of trial treatment.
Contact & Investigator
Bijal Shah, MD
PRINCIPAL INVESTIGATOR
Moffitt Cancer Center
Frequently Asked Questions
Who can join the NCT05581030 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Acute Lymphoblastic Leukemia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05581030 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT05581030 currently recruiting?
Yes, NCT05581030 is actively recruiting participants. Visit ClinicalTrials.gov or contact H. Lee Moffitt Cancer Center and Research Institute to inquire about joining.
Where is the NCT05581030 trial being conducted?
This trial is being conducted at Tampa, United States.
Who is sponsoring the NCT05581030 clinical trial?
NCT05581030 is sponsored by H. Lee Moffitt Cancer Center and Research Institute. The principal investigator is Bijal Shah, MD at Moffitt Cancer Center. The trial plans to enroll 7 participants.
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