NCT07673770 Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
| NCT ID | NCT07673770 |
| Status | Recruiting |
| Phase | — |
| Sponsor | McMaster University |
| Condition | Dementia |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-07-07 |
| Primary Completion | 2028-04-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2026-07-07 with a primary completion date of 2028-04-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker. In people with dementia, it gets much worse, making it harder to talk with others, follow directions, or remember things like shopping lists. This may happen because brain waves that support working memory fall out of sync. Researchers can see these brain waves using a test called EEG. In this study, the investigators will try to get these brain waves back in sync using a safe, non-invasive form of brain stimulation called transcranial magnetic stimulation (TMS), and will time it to each person's brain waves to make it more effective. The goal is to improve working memory in people with dementia. If successful, dementia patients may be able to be more independent taking pressure off their families.
Eligibility Criteria
Inclusion Criteria: * Individuals must be diagnosed with Alzheimer's Disease or related dementias by a clinician. * Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score above 10 on the MMSE * Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English. * Individuals must be at least 55 years or older Exclusion Criteria: * Contraindications to TMS; presence of a pacemaker, metal/electrical/magnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, are taking any prescription medications that increase the risk of seizure. * Allergy to rubbing alcohol, which is needed to prepare electromyography for TMS
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07673770 clinical trial?
This trial is open to participants of all sexes, aged 55 Years or older, studying Dementia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07673770 currently recruiting?
Yes, NCT07673770 is actively recruiting participants. Contact the research team at nelsonaj@mcmaster.ca for enrollment information.
Where is the NCT07673770 trial being conducted?
This trial is being conducted at Hamilton, Canada.
Who is sponsoring the NCT07673770 clinical trial?
NCT07673770 is sponsored by McMaster University. The trial plans to enroll 30 participants.