NCT07285642 Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease
| NCT ID | NCT07285642 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Saglik Bilimleri Universitesi |
| Condition | Copd |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-04-30 |
| Primary Completion | 2026-11-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-04-30 with a primary completion date of 2026-11-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD). Functional near-infrared spectroscopy (fNIRS) and near-infrared spectroscopy (NIRS) will be used simultaneously to measure oxygenation changes in the prefrontal cortex and the vastus lateralis muscle during rest, Stroop task performance, the six-minute walk test, aerobic, strengthening, and breathing exercises. The study will compare COPD patients and age- and sex-matched healthy controls to determine how brain and muscle oxygenation responses differ between groups and among exercise modalities. The findings are expected to guide the design of safe, individualized pulmonary rehabilitation programs that optimize oxygenation without compromising safety.
Eligibility Criteria
Inclusion Criteria * Age 40-70 years * Diagnosis of moderate-to-severe COPD (GOLD stage II-III) * Stable disease (no exacerbation in previous 4 weeks) * BMI 18.5-24.9 kg/m² * Manual muscle strength ≥ 4 (MRC scale) * Ability to perform exercise tests safely * Written informed consent Exclusion Criteria * Severe comorbid conditions (uncontrolled cardiac, neurological, or orthopedic disease) * Need for high-flow oxygen therapy (\>2 L/min) * History of cerebrovascular disease or transient ischemic attack * Musculoskeletal or dermatological conditions impairing NIRS measurement sites * Restrictive lung disease, interstitial lung disease, or small-airway disease * Participation in an exercise program within the last 12 months Healthy Controls * Age 40-70 years * No acute or chronic disease * Non-smoker * BMI 18.5-24.9 kg/m² * No musculoskeletal limitations
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07285642 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, up to 70 Years, studying Copd. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07285642 currently recruiting?
Yes, NCT07285642 is actively recruiting participants. Contact the research team at esra.pehlivan@sbu.edu.tr for enrollment information.
Where is the NCT07285642 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07285642 clinical trial?
NCT07285642 is sponsored by Saglik Bilimleri Universitesi. The trial plans to enroll 60 participants.
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