NCT05232240 Blood Pressure Variability in Non-hypertensive Patients With Ischemic Cerebrovascular Disease
| NCT ID | NCT05232240 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Xuanwu Hospital, Beijing |
| Condition | Ischemic Cerebrovascular Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2022-02-14 |
| Primary Completion | 2027-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2022-02-14 with a primary completion date of 2027-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is a single-center prospective cohort of patients with ischemic cerebrovascular disease (ICVD) who have not met the diagnostic criteria for hypertension. Ambulatory 24-hour blood pressure monitoring (ABPM) will be performed at baseline and one year after the enrollment. The primary purpose of the study is to delineate the relationship of blood pressure variability (BPV) with the risk of composite vascular events in non-hypertensive patients with ICVD. The factors related to BPV, as well as the potential modulators of the associations between BPV and vascular risk, will be further explored among these patients.
Eligibility Criteria
Inclusion Criteria: 1. Diagnosed as ischemic stroke or transient ischemic attack (TIA), with confirmation of computed tomography or magnetic resonance imaging. 2. Less than 90 days after onset of ischemic stroke or TIA symptoms. 3. The blood pressure measured 5\~90 days after the ICVD onset without any anti-hypertension treatment is less than 140/90 mmHg (an average of ≥2 readings obtained on ≥ 2 occasions after emptying bladder, relaxing for more than 5 min, and avoiding caffeine, exercise, or smoking for at least 30 min before measurement). 4. Consent to participate in the study. Exclusion Criteria: 1. A definite diagnosis of hypertension. 2. Under anti-hypertension treatment. 3. Worsening neurological conditions. 4. With a National Institute of Health Stroke Scale score more than 5 points. 5. Intracranial hemorrhage. 6. Autonomic failure. 7. With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 3 years. 8. With contraindications to ambulatory 24-hour blood pressure monitoring or fail to finish the examination at baseline. 9. Mental disease. 10. Pregnant.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05232240 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Ischemic Cerebrovascular Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05232240 currently recruiting?
Yes, NCT05232240 is actively recruiting participants. Contact the research team at maxin118@hotmail.com for enrollment information.
Where is the NCT05232240 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT05232240 clinical trial?
NCT05232240 is sponsored by Xuanwu Hospital, Beijing. The trial plans to enroll 300 participants.