NCT04388943 Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
| NCT ID | NCT04388943 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospitals, Leicester |
| Condition | Cardiovascular Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 9,500 participants |
| Start Date | 2010-06-17 |
| Primary Completion | 2027-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 9,500 participants in total. It began in 2010-06-17 with a primary completion date of 2027-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This project will examine the diagnosis and prognosis of patients with cardiovascular disease in hospital in- and outpatients and compare their characteristics with normal controls from the community. The cardiovascular diseases studied include coronary artery disease, heart failure, heart attacks, valve disease, cardiac surgery, dysrhythmias, aneurysms, embolism, strokes, peripheral vascular disease and hypertension. Current methods for diagnosis and predicting outcome in patients are limited and may lack accuracy. This study will collect clinical details, and blood and urine samples from patients for analysis of proteins, chemicals and genetic biomarkers which will enable an examination of the pathological mechanisms involved in cardiovascular disease. The data will also be used to improve diagnosis and also improve prediction of outcome in patients (future clinical events such as death, further hospitalisation with cardiovascular disease and the effects of any therapy given to the patients). In this way, we can develop accurate ways of assessing a patient's condition and how it could be effectively managed. The study will last for 20 years.
Eligibility Criteria
Inclusion Criteria: * All outpatients and inpatients with cardiovascular disease, of either gender * Aged 18-90 years old * Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain * Healthy volunteers * Aged 18-90 years old * From the community without cardiovascular or other diseases Exclusion Criteria: * Any patient who is unable to give consent * Any patient with non-cardiovascular comorbidity likely to cause death within 6 months * Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material
Contact & Investigator
Nilesh J Samani, Professor
PRINCIPAL INVESTIGATOR
NIHR Leicester Biomedical Research Centre
Frequently Asked Questions
Who can join the NCT04388943 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Cardiovascular Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04388943 currently recruiting?
Yes, NCT04388943 is actively recruiting participants. Contact the research team at emma.beeston@uhl-tr.nhs.uk for enrollment information.
Where is the NCT04388943 trial being conducted?
This trial is being conducted at Leicester, United Kingdom.
Who is sponsoring the NCT04388943 clinical trial?
NCT04388943 is sponsored by University Hospitals, Leicester. The principal investigator is Nilesh J Samani, Professor at NIHR Leicester Biomedical Research Centre. The trial plans to enroll 9,500 participants.