Trial Parameters
Brief Summary
This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per night changes their plasma metabolome and insulin sensitivity. The primary outcome will examine changes in branched-chain amino acids and the secondary outcome will examine changes in insulin sensitivity. The investigators will also determine if changes in plasma metabolites can be used as a biomarker to discriminate between adequate versus insufficient sleep.
Eligibility Criteria
Inclusion Criteria: 1. 18-35 years old; men and women a. Equal numbers of women and men will be included. 2. Body Mass Index (BMI) of \> 18.5 and \<24.9. 3. Inactive to habitual moderate physical activity level (\<5 days of exercise per week). 4. Sleep/wake history: habitual sleep duration less than 6 hours per night. 5. Altitude history: Potential participants must have lived at Denver altitude or higher for at least 3 months. Exclusion Criteria: 1. Any clinically significant unstable medical or surgical condition within the last year (treated or untreated). 2. Any clinically significant psychiatric condition, as defined by DSM-IV-TR. I 3. Any clinically significant sleep disorder. 4. Use of prescription medications/supplements within one month or need of these medications at any time during the study. 5. Symptoms of active illness (e.g., fever). 6. Uncorrected visual impairment 7. History of shift work in prior year or travel more than one time zone in three weeks prior to study. 8.