NCT05540561 Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse

Eligibility & Interventions

Eligibility Fast-Check

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What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 356 participants in total. It began in 2023-01-30 with a primary completion date of 2026-07-30.

Brief Summary

There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord. One thus frequently observes patients presenting disorders of walking or paresthesias, of more or less resolving evolution being able to go until the need for using a wheelchair and more recently cases of thrombosis were reported Serum or urine N2O assays are rarely performed routinely, because they do not allow to ensure a real exposure due to the very short half-life of this gas in the body. Thus, other biological monitoring markers are mentioned in the literature, such as vitamin B12 or homocysteine. Unfortunately, there are still no recommendations for biological monitoring of nitrous oxide consumption. Moreover, underlying mechanisms leading to clinical outcomes remains misunderstood.

Eligibility Criteria

Inclusion Criteria: * A current or former recreational nitrous oxide user defined * With associated clinical signs (group 1) * Without associated clinical signs (group 2) * With or without clinico-biological sequelae associated with use * Consenting to the conduct of the study * Socially insured Exclusion Criteria: * Pregnant or breastfeeding women * Never used nitrous oxide or stopped using it more than 6 months ago * Lack of social security coverage * Not willing to participate in the entire study

Contact & Investigator

Frequently Asked Questions