NCT05760846 Bimanual Motor Skill Learning in Acute Stroke
| NCT ID | NCT05760846 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital of Mont-Godinne |
| Condition | Stroke, Acute |
| Study Type | INTERVENTIONAL |
| Enrollment | 160 participants |
| Start Date | 2023-04-17 |
| Primary Completion | 2028-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 160 participants in total. It began in 2023-04-17 with a primary completion date of 2028-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The subacute phase of stroke provides a window into how a lesion perturbs sensorimotor functions prior to reorganisation driven by plasticity and neurorehabilitation. The recovery from motor impairment has been extensively studied, but it is currently unknown whether motor skill learning (MSkL) is enhanced or impaired during acute stroke, especially bimanual motor skill learning (bim-MSkL), which likely requires more motor-attentional-cognitive resources than unimanual MSkL. The goals of this project are: to determine the neural substrates critical to achieve proximal and distal bimanual motor skill learning (bim-MSkL) by specifying whether (sub)acute stroke to different brain areas (cortical and subcortical) induce specific deficits in bimanual and/or distal bim-MSkL, which behavioral components are involved in bim-MSkL, and whether damage to the motor, sensory and inter-hemispheric pathways specifically impairs proximal and/or distal bim-MSkL.
Eligibility Criteria
ACUTE STROKE PATIENTS: Inclusion Criteria: * acute stroke (\< 21 days) * aged 18-90 years * with a demonstrated stroke (ischemic or hemorrhagic) lesion on brain imaging Exclusion Criteria: * " classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...) * difficulty in understanding or executing commands * drug/alcohol abuse * severe aphasia / cognitive deficits interfering with study * inability to complete the tasks (i.e. full paralysis of the arm) * multiple strokes / dementia / psychiatric condition HEALTHY INDIVIDUALS: Inclusion Criteria: • 18-90 years Exclusion Criteria: * medical history with a previous stroke / relevant neurological deficit * drug/alcohol abuse * psychiatric condition/ dementia
Contact & Investigator
Yves Vandermeeren, MD, PhD
PRINCIPAL INVESTIGATOR
UCLouvain IONS
Frequently Asked Questions
Who can join the NCT05760846 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Stroke, Acute. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05760846 currently recruiting?
Yes, NCT05760846 is actively recruiting participants. Contact the research team at yves.vandermeeren@uclouvain.be for enrollment information.
Where is the NCT05760846 trial being conducted?
This trial is being conducted at Yvoir, Belgium, Yvoir, Belgium.
Who is sponsoring the NCT05760846 clinical trial?
NCT05760846 is sponsored by University Hospital of Mont-Godinne. The principal investigator is Yves Vandermeeren, MD, PhD at UCLouvain IONS. The trial plans to enroll 160 participants.
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