NCT07569445 Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
| NCT ID | NCT07569445 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Rochester |
| Condition | Rett Syndrome |
| Study Type | OBSERVATIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-07-31 |
| Primary Completion | 2027-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 60 participants in total. It began in 2025-07-31 with a primary completion date of 2027-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome. Participants will complete a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. In addition, parents or caregivers will complete questionnaires and an interview about the participant's symptoms, communication abilities, daily functioning and overall health. The information collected from this study may help researchers better understand brain activity patterns and clinical features associated with Rett syndrome and support future research efforts.
Eligibility Criteria
Rett Syndrome Participants: Inclusion Criteria: * Have a clinical diagnosis of classic Rett syndrome * Have a pathogenic MECP2 genetic variant confirmed via genetic testing * Are past the clinical regression stage * Are within the eligible age range for the study (2 years or older) * Are able to tolerate the noninvasive EEG recording * Parent or caregiver is willing and able to provide parental permission and complete questionnaires and interviews Exclusion Criteria: * Experiences hearing impairment or hearing loss * Presence of medical conditions that would prevent safe participation in EEG recording * Inability to tolerate EEG procedures * Any condition that in the opinion of the investigator would interfere with study participation or data quality Controls Inclusion Criteria: * Neurologically healthy individuals ages 2 years or older * Are able to tolerate the noninvasive EEG recording Exclusion Criteria: * Experiences hearing impairment or hearing loss * Medical history of genetic, neurological, or psychiatric disorders * History of special education services * Inability to tolerate EEG procedures * Any condition that in the opinion of the investigator would interfere with study participation or data quality
Frequently Asked Questions
Who can join the NCT07569445 clinical trial?
This trial is open to participants of all sexes, aged 2 Years or older, studying Rett Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07569445 currently recruiting?
Yes, NCT07569445 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of Rochester to inquire about joining.
Where is the NCT07569445 trial being conducted?
This trial is being conducted at Rochester, United States.
Who is sponsoring the NCT07569445 clinical trial?
NCT07569445 is sponsored by University of Rochester. The trial plans to enroll 60 participants.