NCT07325448 Assessing MB-Spirit for Psychological Well-being
| NCT ID | NCT07325448 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sara W Lazar |
| Condition | Stress |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2026-03-15 |
| Primary Completion | 2026-11 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 44 participants in total. It began in 2026-03-15 with a primary completion date of 2026-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to test two new behavioral interventions designed to reduce stress and improve spiritual well-being in stressed adults. The main questions it aims to answer are: 1. Can the program decrease stress and improve spiritual well-being? 2. What brain changes accompany participation in the programs? Participants will: 1. Be randomized to either a live online course that meets for 90 minutes every week for 8-weeks, or to a self-paced program. In the self-paced program, participants will receive materials once a week and can work through them at their own pace. Both programs are designed to decrease stress and improve well-being. 2. Complete questionnaires before and after the course. 3. Complete and interview before and after the course. 4. A subset of people will be randomized to complete an MRI scan of their brain before and after the course. Participants will be randomized to either take the course right away, or be put on a wait-list. Those on the wait-list will undergo the testing at 2 timepoints before they start the program.
Eligibility Criteria
Inclusion Criteria: * Understands English * Able to attend all 8 classes * Able to travel to Boston for MRI scans Exclusion Criteria: * claustrophobia, pregnancy, head trauma, metallic implants or devices contraindicating MRI, left-handed, conditions that alter cerebral blood flow or metabolism (e.g. stroke), current use of psychotropic medications, lifetime history of suicidality, homicidally, self-destructive acts, schizophrenia or psychosis.
Contact & Investigator
Sara Lazar, PhD
PRINCIPAL INVESTIGATOR
Massachusetts General Hospital
Frequently Asked Questions
Who can join the NCT07325448 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Stress. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07325448 currently recruiting?
Yes, NCT07325448 is actively recruiting participants. Contact the research team at slazar@mgh.harvard.edu for enrollment information.
Where is the NCT07325448 trial being conducted?
This trial is being conducted at Boston, United States, Boston, United States.
Who is sponsoring the NCT07325448 clinical trial?
NCT07325448 is sponsored by Sara W Lazar. The principal investigator is Sara Lazar, PhD at Massachusetts General Hospital. The trial plans to enroll 44 participants.